Mirian Hayashi
生駒 : 奈良先端科学技術大学院大学, 2020.2
Lecture ArchiveNeurodegenerative disorders characterized pathologically by cytoplasmic malformed proteins and consequent complex formation have recently attracted the attention of several scientists. Ndel1 (Nuclear distribution element-like 1) enzyme activity was shown to be important for neuritogenesis and neuron migration, with potential contribution for brain formation, which mechanism was associated to its ability to bind to the protein product of a gene previously associated to schizophrenia (SCZ) susceptibility, namely DISC1 (Disrupted-in-Schizophrenia 1). Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient’s livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders have been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, Ndel1 possess oligopeptidase actitivity, as well as other members of this class of enzymes, namely Angiotensin I-Converting Enzyme (ACE) and prolyl-oligopeptidase (POP), share natural substrates with Ndel1. Few genetic association studies yielded inconclusive results for oligopeptidases role in schizophrenia.
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M017056 |
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2019
電子化映像資料（1時間 23分26秒）
情報科学領域・コロキアム ; 2019年度
講演者所属: Universidade Federal de São Paulo
講演日: 2020年2月5日
講演場所: エーアイ大講義室（L1）
Japan
Japanese (jpn)
English (eng)
