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BMP-induced REST regulates the establishment and maintenance of astrocytic identity

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dc.contributor.author Jun Kohyama en
dc.contributor.author Tsukasa Sanosaka en
dc.contributor.author Akinori Tokunaga en
dc.contributor.author Eriko Takatsuka en
dc.contributor.author Keita Tsujimura en
dc.contributor.author Hideyuki Okano en
dc.contributor.author Kinichi Nakashima en
dc.date.accessioned 2012-10-03T01:57:35Z en
dc.date.available 2012-10-03T01:57:35Z en
dc.date.issued 2010-04 en
dc.identifier.issn 0021-9525 en
dc.identifier.uri http://hdl.handle.net/10061/8566 en
dc.description.abstract Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation remains unclear. In the mammalian central nervous system, neurons, astrocytes, and oligodendrocytes are generated throughout life from common tripotent neural progenitor cells (NPCs). Bone morphogenetic proteins (BMPs) are well-known astrocyte-inducing cytokines. We show here that the expression of a transcriptional repressor, RE1 silencer of transcription (REST)/neuron-restrictive silencer factor (NRSF), is up-regulated and sustained by BMP signal activation in the course of astrocytic differentiation of NPCs, and restricts neuronal differentiation. We further show that, in differentiated astrocytes, endogenous REST/NRSF associates with various neuronal genes and that disruption of its function resulted in their derepression, thereby explaining how ectopic neuronal gene expression is prevented in cells with astrocytic traits. Collectively, our results suggest that REST/NRSF functions as a molecular regulator of the nonneuronal phenotype in astrocytes. en
dc.language.iso en en
dc.publisher Rockefeller University Press en
dc.rights Copyright (C) 2010 Rockefeller University Press. en
dc.title BMP-induced REST regulates the establishment and maintenance of astrocytic identity en
dc.type.nii Journal Article en
dc.textversion Publisher en
dc.identifier.ncid AA00694812 en
dc.identifier.jtitle The Journal of Cell Biology en
dc.identifier.volume 189 en
dc.identifier.issue 1 en
dc.identifier.spage 159 en
dc.identifier.epage 170 en
dc.relation.doi 10.1083/jcb.200908048 en

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