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Browsing バイオサイエンス研究科 / Graduate School of Biological Sciences by Title

Browsing バイオサイエンス研究科 / Graduate School of Biological Sciences by Title

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  • Mai, Chi Thanh; Le, Quynh Giang; Ishiwata-Kimata, Yuki; Takagi, Hiroshi; Kohno, Kenji; Kimata, Yukio (Oxford University Press, 2018-03-01)
    Accumulation of unfolded secretory proteins in the endoplasmic reticulum (ER), namely ER stress, is hazardous to eukaryotic cells and promotes the unfolded protein response (UPR). Ire1 is an ER-located transmembrane protein ...
  • Katsuno, Hiroko; Toriyama, Michinori; Hosokawa, Yoichiroh; Mizuno, Kensaku; Ikeda, Kazushi; Sakumura, Yuichi; Inagaki, Naoyuki (Elsevier, 2015-07-16)
    Actin and actin-associated proteins migrate within various cell types. To uncover the mechanism of their migration, we analyzed actin waves, which translocate actin and actin-associated proteins along neuronal axons toward ...
  • Inagaki, Naoyuki; Katsuno, Hiroko (Cell Press, 2017-03-07)
    Actin filaments and associated proteins undergo wave-like movement in various cell types. Recent studies with cutting-edge analyses, including live-cell imaging, biophysical monitoring and manipulation, and mathematical ...
  • Takatsuka, Hirotomo; Ohno, Ryoko; Umeda, Masaaki (Wiley/Blackwell (10.1111), 2009-07-24)
    Summary Cyclin-dependent kinases (CDKs) play an essential role in cell cycle regulation during the embryonic and post-embryonic development of various organisms. Full activation of CDKs requires not only binding to cyclins ...
  • Chen, Poyu; Takatsuka, Hirotomo; Takahashi, Naoki; Kurata, Rie; Fukao, Yoichiro; Kobayashi, Kosuke; Ito, Masaki; Umeda, Masaaki (Springer Nature, 2017-09-21)
    Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type ...
  • Waki, Takamitsu; Hiki, Takeshi; Watanabe, Ryouhei; Hashimoto, Takashi; Nakajima, Keiji (Elsevier (Cell Press), 2011-07-28)
    Morphogenesis of seed plants commences with highly stereotypical cell division sequences in early embryogenesis [1, 2]. Although a small number of transcription factors and a mitogen-activated protein kinase (MAP) cascade ...
  • Izuho Hatada; Masakazu Namihira; Sumiyo Morita; Mika Kimura; Takuro Horii; Kinichi Nakashima (Public Library of Science, 2008-09-11)
    Epigenetic changes are thought to lead to alterations in the property of cells, such as differentiation potential. Neural precursor cells (NPCs) differentiate only into neurons in the midgestational brain, yet they become ...
  • Yoshiyama, Kaoru O; Kobayashi, Junya; Ogita, Nobuo; Ueda, Minako; Kimura, Seisuke; Maki, Hisaji; Umeda, Masaaki (EMBO, 2013-08-02)
    Arabidopsis SOG1 (suppressor of gamma response 1) is a plant‐specific transcription factor that governs the DNA damage response. Here we report that SOG1 is phosphorylated in response to DNA damage, and that this phosphorylation ...
  • Kanda, Satoshi; Yanagitani, Kota; Yokota, Yukiko; Esaki, Yuta; Kohno, Kenji (National Academy of Sciences of the United States of America, 2016-09-20)
    Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress ...
  • Davidson, Alice E; Liskova, Petra; Evans, Cerys J; Dudakova, Lubica; Noskova, Lenka; Pontikos, Nikolas; Hartmannova, Hana; Hodanova, Katerina; Stranecky, Viktor; Kozmik, Zbynek; Levis, Hannah J; Idigo, Nwamaka; Sasai, Noriaki; Maher, Geoffrey J; Bellingham, James; Veli, Neyme; Ebenezer, Neil D; Cheetham, Michael E; Daniels, Julie T; Thaung, Caroline M.H; Jirsova, Katerina; Plagnol, Vincent; Filipec, Martin; Kmoch, Stanislav; Tuft, Stephen J; Hardcastle, Alison J (Cell Press, 2017-01-07)
    Congenital hereditary endothelial dystrophy 1 (CHED1) and posterior polymorphous corneal dystrophy 1 (PPCD1) are autosomal-dominant corneal endothelial dystrophies that have been genetically mapped to overlapping loci on ...
  • Ito, Jun; Fukaki, Hidehiro; Onoda, Makoto; Li, Lin; Li, Chuanyou; Tasaka, Masao; Furutani, Masahiko (National Academy of Sciences, 2016-05-23)
    Mediator is a multiprotein complex that integrates the signals from transcription factors binding to the promoter and transmits them to achieve gene transcription. The subunits of Mediator complex reside in four modules: ...
  • Jun Kohyama; Tsukasa Sanosaka; Akinori Tokunaga; Eriko Takatsuka; Keita Tsujimura; Hideyuki Okano; Kinichi Nakashima (Rockefeller University Press, 2010-04)
    Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation ...
  • Iwano, Megumi; Ito, Kanae; Fujii, Sota; Kakita, Mitsuru; Asano-Shimosato, Hiroko; Igarashi, Motoko; Kaothien-Nakayama, Pulla; Entani, Tetsuyuki; Kanatani, Asaka; Takehisa, Masashi; Tanaka, Masaki; Komatsu, Kunihiko; Shiba, Hiroshi; Nagai, Takeharu; Miyawaki, Atsushi; Isogai, Akira; Takayama, Seiji (Nature Publishing Group, 2015-09-01)
    Self-incompatibility in the Brassicaceae is controlled by multiple haplotypes encoding the pollen ligand (S-locus protein 11, SP11, also known as S-locus cysteine-rich protein, SCR) and its stigmatic receptor (S-receptor ...
  • Alseekh, Saleh; Tong, Hao; Scossa, Federico; Brotman, Yariv; Vigroux, Florian; Tohge, Takayuki; Ofner, Itai; Zamir, Dani; Nikoloski, Zoran; Fernie, Alisdair R. (American Society of Plant Biologists, 2017-11-01)
    To explore the genetic robustness (canalization) of metabolism, we examined the levels of fruit metabolites in multiple harvests of a tomato introgression line (IL) population. The IL partitions the whole genome of the ...
  • Matsui, Takaaki; Thitamadee, Siripong; Murata, Tomoko; Kakinuma, Hisaya; Nabetani, Takuji; Hirabayashi, Yoshio; Hirate, Yoshikazu; Okamoto, Hitoshi; Bessho, Yasumasa (National Academy of Science, 2011-06-14)
    The assembly of progenitor cells is a crucial step for organ formation during vertebrate development. Kupffer’s vesicle (KV) is a key organ required for the left-right asymmetric body plan in zebrafish, and is generated ...
  • Inagaki, Soichi; Umeda, Masaaki (Elsevier, 2011-11-01)
    The cell cycle is driven by the activity of cyclin-dependent kinase (CDK)–cyclin complexes. Therefore, internal and external signals converge on the regulation of CDK–cyclin activity to modulate cell proliferation in ...
  • Takeuchi, Rikiya; Tamura, Takeyuki; Nakayashiki, Toru; Tanaka, Yuichirou; Muto, Ai; Wanner, Barry L.; Mori, Hirotada (BioMed Central Ltd, 2014-06-26)
    Precise quantitative growth measurements and detection of small growth changes in high-throughput manner is essential for fundamental studies of bacterial cell. However, an inherent tradeoff for measurement quality in ...
  • Yamamoto, Tatsuo; Takano, Tomomi; Higuchi, Wataru; Iwao, Yasuhisa; Singur, Olga; Reva, Ivan; Otsuka, Yuta; Nakayashiki, Toru; Mori, Hirotada; Reva, Galina; Kuznetsov, Vladimir; Potapov, Vladimir (Public Library of Science, 2012-01-19)
    Two distinct classes of methicillin-resistant Staphylococcus aureus (MRSA) are spreading in hospitals (as hospital-acquired MRSA, HA-MRSA) and in the community (as community-acquired MRSA, CA-MRSA). Multilocus sequence ...
  • Yasuda, Shinsuke; Wada, Yuko; Kakizaki, Tomohiro; Tarutani, Yoshiaki; Miura-Uno, Eiko; Murase, Kohji; Fujii, Sota; Hioki, Tomoya; Shimoda, Taiki; Takada, Yoshinobu; Shiba, Hiroshi; Takasaki-Yasuda, Takeshi; Suzuki, Go; Watanabe, Masao; Takayama, Seiji (Macmillan Publishers Limited, 2016-12-22)
    In diploid organisms, phenotypic traits are often biased by effects known as Mendelian dominant–recessive interactions between inherited alleles. Phenotypic expression of SP11 alleles, which encodes the male determinants ...
  • Yamada, Tatsuya; Nishiyama, Makoto; Oba, Shigeyuki; Jimbo, Henri Claver; Ikeda, Kazushi; Ishii, Shin; Hong, Kyonsoo; Sakumura, Yuichi (Nature Publishing Group, 2018-03-14)
    Biological cells express intracellular biomolecular information to the extracellular environment as various physical responses. We show a novel computational approach to estimate intracellular biomolecular pathways from ...

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