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Browsing バイオサイエンス研究科 / Graduate School of Biological Sciences by Subject "X-ray crystallography"

Browsing バイオサイエンス研究科 / Graduate School of Biological Sciences by Subject "X-ray crystallography"

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  • Kumazaki, Kaoru; Kishimoto, Toshiki; Furukawa, Arata; Mori, Hiroyuki; Tanaka, Yoshiki; Dohmae, Naoshi; Ishitani, Ryuichiro; Tsukazaki, Tomoya; Nureki, Osamu (Macmillan Publishers, 2014-12-03)
    Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, ...
  • Nasuno, Ryo; Hirano, Yoshinori; Itoh, Takafumi; Hakoshima, Toshio; Hibi, Takao; Takagi, Hiroshi (National Academy of Sciences, 2013-07-01)
    Mpr1 (sigma1278b gene for proline-analog resistance 1), which was originally isolated as N-acetyltransferase detoxifying the proline analog L-azetidine-2-carboxylate, protects yeast cells from various oxidative stresses. ...
  • Kim, Sun-Yong; Tachioka, Yuka; Mori, Tomoyuki; Hakoshima, Toshio (Nature Publishing Group, 2016-06-23)
    MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. MOB1 is present in an autoinhibited form and is activated by MST1/2-mediated phosphorylation, although the precise ...
  • Doki, Shintaro; Kato, Hideaki E.; Solcan, Nicolae; Iwaki, Masayo; Koyama, Michio; Hattori, Motoyuki; Iwase, Norihiko; Tsukazaki, Tomoya; Sugita, Yuji; Kandori, Hideki; Newstead, Simon; Ishitani, yuichiro; Nureki, Osamu (National Academy of Sciences, 2013-07-09)
    Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H+ gradient across the membrane. ...
  • Tanaka, Yoshiki; Hipolito, Christopher J.; Maturana, Andres D.; Ito, Koichi; Kuroda, Teruo; Higuchi, Takashi; Katoh, Takayuki; Kato, Hideaki E.; Hattori, Motoyuki; Kumazaki, Kaoru; Tsukazaki, Tomoya; Ishitani, Ryuichiro; Suga, Hiroaki; Nureki, Osamu (Nature Publishing Group, a division of Macmillan Publishers, 2013-03-27)
    Multidrug and toxic compound extrusion (MATE) family transporters are conserved in the three primary domains of life (Archaea, Bacteria and Eukarya), and export xenobiotics using an electrochemical gradient of H+ or Na+ ...
  • Kumazaki, Kaoru; Chiba, Shinobu; Takemoto, Mizuki; Furukawa, Arata; Nishiyama, Ken-ichi; Sugano, Yasunori; Mori, Takaharu; Dohmae, Naoshi; Hirata, Kunio; Nakada-Nakura, Yoshiko; Maturana, Andrés D.; Tanaka, Yoshiki; Mori, Hiroyuki; Sugita, Yuji; Arisaka, Fumio; Ito, Koreaki; Ishitani, Ryuichiro; Tsukazaki, Tomoya; Nureki, Osamu (Nature Publishing Group, 2014-05-22)
    Newly synthesized membrane proteins must be accurately inserted into the membrane, folded and assembled for proper functioning. The protein YidC inserts its substrates into the membrane, thereby facilitating membrane protein ...
  • Chek, Min Fey; Kim, Sun-Yong; Mori, Tomoyuki; Arsad, Hasni; Samian, Mohammed Razip; Sudesh, Kumar; Hakoshima, Toshio (Macmillan Publishers Limited, part of Springer Nature., 2017-07-13)
    Polyhydroxyalkanoate (PHA) is a promising candidate for use as an alternative bioplastic to replace petroleum-based plastics. Our understanding of PHA synthase PhaC is poor due to the paucity of available three-dimensional ...
  • Kim, Sun-Yong; Hakoshima, Toshio; Kitano, Ken (Nature Publishing Group, 2013-11-21)
    Bloom syndrome is a rare genetic disorder characterized by genomic instability and cancer predisposition. The disease is caused by mutations of the Bloom syndrome protein (BLM). Here we report the crystal structure of a ...

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