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Intergenerational effect of short-term spaceflight in mice

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dc.contributor.author Yoshida, Keisuke en
dc.contributor.author Fujita, Shin-ichiro en
dc.contributor.author Isotani, Ayako en
dc.contributor.author Kudo, Takashi en
dc.contributor.author Takahashi, Satoru en
dc.contributor.author Ikawa, Masahito en
dc.contributor.author Shiba, Dai en
dc.contributor.author Shirakawa, Masaki en
dc.contributor.author Muratani, Masafumi en
dc.contributor.author Ishii, Shunsuke en
dc.date.accessioned 2021-12-09T02:53:22Z en
dc.date.available 2021-12-09T02:53:22Z en
dc.date.issued 2021-07-23 en
dc.identifier.uri http://hdl.handle.net/10061/14573 en
dc.description.abstract As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect. en
dc.language.iso en en
dc.publisher Cell Press en
dc.relation.isreplacedby https://www.sciencedirect.com/science/article/pii/S2589004221007410?via%3Dihub en
dc.rights © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). ja
dc.title Intergenerational effect of short-term spaceflight in mice en
dc.type.nii Journal Article en
dc.contributor.transcription イソタニ, アヤコ ja
dc.contributor.alternative 磯谷, 綾子 ja
dc.textversion none en
dc.identifier.eissn 2589-0042 en
dc.identifier.jtitle iScience en
dc.identifier.volume 24 en
dc.identifier.issue 7 en
dc.relation.doi 10.1016/j.isci.2021.102773 en
dc.identifier.NAIST-ID 74653114 en
dc.relation.pmid 34278272 en


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