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Sulfur availability regulates plant growth via glucose-TOR signaling

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dc.contributor.author Dong, Yihan en
dc.contributor.author Silbermann, Marleen en
dc.contributor.author Speiser, Anna en
dc.contributor.author Forieri, Ilaria en
dc.contributor.author Linster, Eric en
dc.contributor.author Poschet, Gernot en
dc.contributor.author Samami, Arman Allboje en
dc.contributor.author Watanabe, Mutsumi en
dc.contributor.author Sticht, Carsten en
dc.contributor.author Teleman, Aurelio A. en
dc.contributor.author Deragon, Jean-Marc en
dc.contributor.author Saito, Kazuki en
dc.contributor.author Hell, Rüdiger ja
dc.contributor.author Wirtz, Markus en
dc.date.accessioned 2021-06-28T06:13:41Z en
dc.date.available 2021-06-28T06:13:41Z en
dc.date.issued 2017-10-27 en
dc.identifier.uri http://hdl.handle.net/10061/14377 en
dc.description.abstract Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental question is how amino acid sensing is achieved in photo-autotrophic organisms. Here we demonstrate that the plant Arabidopsis does not sense the sulfur-containing amino acid cysteine itself, but its biosynthetic precursors. We identify the kinase GCN2 as a sensor of the carbon/nitrogen precursor availability, whereas limitation of the sulfur precursor is transduced to TOR by downregulation of glucose metabolism. The downregulated TOR activity caused decreased translation, lowered meristematic activity, and elevated autophagy. Our results uncover a plant-specific adaptation of TOR function. In concert with GCN2, TOR allows photo-autotrophic eukaryotes to coordinate the fluxes of carbon, nitrogen, and sulfur for efficient cysteine biosynthesis under varying external nutrient supply. en
dc.language.iso en en
dc.publisher Nature Research en
dc.relation.isreplacedby https://www.nature.com/articles/s41467-017-01224-w en
dc.rights © The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. ja
dc.subject Plant physiology en
dc.subject Plant signalling en
dc.subject TOR signalling en
dc.title Sulfur availability regulates plant growth via glucose-TOR signaling en
dc.type.nii Journal Article en
dc.contributor.transcription ワタナベ, ムツミ ja
dc.contributor.alternative 渡辺, むつみ ja
dc.textversion none en
dc.identifier.eissn 2041-1723 en
dc.identifier.jtitle Nature Communications en
dc.identifier.volume 8 en
dc.relation.doi 10.1038/s41467-017-01224-w en
dc.identifier.artnum 1174 en
dc.identifier.NAIST-ID 74653866 en
dc.relation.pmid 29079776 en

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