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Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence

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dc.contributor.author Kamranfar, Iman en
dc.contributor.author Xue, Gang-Ping en
dc.contributor.author Tohge, Takayuki en
dc.contributor.author Sedaghatmehr, Mastoureh en
dc.contributor.author Fernie, Alisdair R. en
dc.contributor.author Balazadeh, Salma en
dc.contributor.author Mueller-Roeber, Bernd en
dc.date.accessioned 2021-06-14T02:15:28Z en
dc.date.available 2021-06-14T02:15:28Z en
dc.date.issued 2018-04-16 en
dc.identifier.uri http://hdl.handle.net/10061/14299 en
dc.description.abstract Leaf senescence is a key process in plants that culminates in the degradation of cellular constituents and massive reprogramming of metabolism for the recovery of nutrients from aged leaves for their reuse in newly developing sinks. We used molecular–biological and metabolomics approaches to identify NAC transcription factor (TF) RD26 as an important regulator of metabolic reprogramming in Arabidopsis thaliana. RD26 directly activates CHLOROPLAST VESICULATION (CV), encoding a protein crucial for chloroplast protein degradation, concomitant with an enhanced protein loss in RD26 overexpressors during senescence, but a reduced decline of protein in rd26 knockout mutants. RD26 also directly activates LKR/SDH involved in lysine catabolism, and PES1 important for phytol degradation. Metabolic profiling revealed reduced γ-aminobutyric acid (GABA) in RD26 overexpressors, accompanied by the induction of respective catabolic genes. Degradation of lysine, phytol and GABA is instrumental for maintaining mitochondrial respiration in carbon-limiting conditions during senescence. RD26 also supports the degradation of starch and the accumulation of mono- and disaccharides during senescence by directly enhancing the expression of AMY1, SFP1 and SWEET15 involved in carbohydrate metabolism and transport. Collectively, during senescence RD26 acts by controlling the expression of genes across the entire spectrum of the cellular degradation hierarchy. ja
dc.language.iso en en
dc.publisher Wiley/Blackwell en
dc.relation.isreplacedby https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.15127 en
dc.rights © 2018 The Authors New Phytologist © 2018 New Phytologist Trust This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ja
dc.subject Arabidopsis en
dc.subject fatty acid en
dc.subject primary metabolism en
dc.subject protein and amino acid degradation en
dc.subject respiration en
dc.subject senescence en
dc.title Transcription factor RD26 is a key regulator of metabolic reprogramming during dark-induced senescence en
dc.type.nii Journal Article en
dc.contributor.transcription トウゲ, タカユキ ja
dc.contributor.alternative 峠, 隆之 ja
dc.textversion none en
dc.identifier.eissn 1469-8137 en
dc.identifier.jtitle New Phytologist en
dc.identifier.volume 218 en
dc.identifier.issue 4 en
dc.identifier.spage 1543 en
dc.identifier.epage 1557 en
dc.relation.doi 10.1111/nph.15127 en
dc.identifier.NAIST-ID 74653593 en
dc.relation.pmid 29659022 en


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