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Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium

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dc.contributor.author Israeli, Alon en
dc.contributor.author Burko, Yogev en
dc.contributor.author Shleizer-Burko, Sharona en
dc.contributor.author Zelnik, Iris Daphne en
dc.contributor.author Sela, Noa en
dc.contributor.author Hajirezaei, Mohammad R. en
dc.contributor.author Fernie, Alisdair R. en
dc.contributor.author Tohge, Takayuki en
dc.contributor.author Ori, Naomi en
dc.contributor.author Bar, Maya en
dc.date.accessioned 2021-05-28T04:42:21Z en
dc.date.available 2021-05-28T04:42:21Z en
dc.date.issued 2021-04-26 en
dc.identifier.uri http://hdl.handle.net/10061/14279 en
dc.description.abstract Morphogenesis and differentiation are important stages in organ development and shape determination. However, how they are balanced and tuned during development is not fully understood. In the compound leaved tomato, an extended morphogenesis phase allows for the initiation of leaflets, resulting in the compound form. Maintaining a prolonged morphogenetic phase in early stages of compound-leaf development in tomato is dependent on delayed activity of several factors that promote differentiation, including the CIN-TCP transcription factor (TF) LA, the MYB TF CLAU and the plant hormone Gibberellin (GA), as well as on the morphogenesis-promoting activity of the plant hormone cytokinin (CK). Here, we investigated the genetic regulation of the morphogenesis-differentiation balance by studying the relationship between LA, CLAU, TKN2, CK and GA. Our genetic and molecular examination suggest that LA is expressed earlier and more broadly than CLAU and determines the developmental context of CLAU activity. Genetic interaction analysis indicates that LA and CLAU likely promote differentiation in parallel genetic pathways. These pathways converge downstream on tuning the balance between CK and GA. Comprehensive transcriptomic analyses support the genetic data and provide insights into the broader molecular basis of differentiation and morphogenesis processes in plants. en
dc.language.iso en en
dc.publisher Public Library of Science en
dc.relation.isreplacedby https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009537#abstract0 en
dc.rights © 2021 Israeli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ja
dc.title Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium en
dc.type.nii Journal Article en
dc.contributor.transcription トウゲ, タカユキ ja
dc.contributor.alternative 峠, 隆之 ja
dc.textversion none en
dc.identifier.eissn 1553-7404 en
dc.identifier.jtitle PLOS Genetics en
dc.identifier.volume 17 en
dc.identifier.issue 4 en
dc.relation.doi 10.1371/journal.pgen.1009537 en
dc.identifier.artnum e1009537 en
dc.identifier.NAIST-ID 74653593 en
dc.relation.pmid 33901177 en


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