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Sox14 is essential for initiation of interneuron differentiation in the chick spinal cord

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dc.contributor.author Taiki, Katsuyama en
dc.contributor.author Minori, Kadoya en
dc.contributor.author Manabu, Shirai en
dc.contributor.author Noriaki, Sasai en
dc.date.accessioned 2021-04-26T11:29:44Z en
dc.date.available 2021-04-26T11:29:44Z en
dc.date.issued 2021-02-26 en
dc.identifier.uri http://hdl.handle.net/10061/14251 en
dc.description.abstract The neural tube comprises several different types of progenitors and postmitotic neurons that coordinately act with each other to play integrated functions. Its development consists of two phases: proliferation of progenitor cells and differentiation into postmitotic neurons. How progenitor cells differentiate into each corresponding neuron is an important question for understanding the mechanisms of neuronal development. Here we introduce one of the Sox transcription factors, Sox14, which plays an essential role in the promotion of neuronal differentiation. Sox14 belongs to the SoxB subclass and its expression starts in the progenitor regions before neuronal differentiation is initiated at the trunk level of the neural tube. After neuronal differentiation is initiated, Sox14 expression gradually becomes confined to the V2a region of the neural tube, where Chx10 is co-expressed. Overexpression of Sox14 restricts progenitor cell proliferation. Conversely, the blockade of Sox14 expression by the RNAi strategy inhibits V2a neuron differentiation and causes expansion of the progenitor domain. We further found that Sox14 acted as a transcriptional activator. Taken together, Sox14 acts as a modulator of cell proliferation and an initiator protein for neuronal differentiation in the intermediate region of the neural tube. en
dc.language.iso en en
dc.publisher Research Square Company en
dc.relation.isreplacedby https://www.researchsquare.com/article/rs-243180/v1 en
dc.rights ©2021 Author(s).This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) Research Square preprints are published under a CC-BY 4.0 license, meaning the author retains full copyright for their work. Readers are able to reuse the content under the rules of the CC-BY license. ja
dc.subject Nerual Tube en
dc.subject Progenitor Cells en
dc.subject Postmitotic Neurons en
dc.subject Sox Transcription Factors en
dc.subject V2a region en
dc.title Sox14 is essential for initiation of interneuron differentiation in the chick spinal cord en
dc.type.nii Journal Article en
dc.contributor.transcription カツヤマ, タイキ ja
dc.contributor.transcription カドヤ, ミノリ ja
dc.contributor.transcription ササイ, ノリアキ ja
dc.contributor.alternative 勝山, 大暉 ja
dc.contributor.alternative 角谷, 美典 ja
dc.contributor.alternative 笹井, 紀明 ja
dc.textversion author en
dc.identifier.jtitle Research Square en
dc.relation.doi 10.21203/rs.3.rs-243180/v1 en
dc.identifier.NAIST-ID 86636883 en
dc.identifier.NAIST-ID 85622108 en
dc.identifier.NAIST-ID 74651969 en

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