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Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases

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dc.contributor.author Ahmed, Rezwana
dc.contributor.author Nakahata, Yasukazu
dc.contributor.author Shinohara, Kazuyuki
dc.contributor.author Bessho, Yasumasa
dc.date.accessioned 2021-03-05T08:34:41Z
dc.date.available 2021-03-05T08:34:41Z
dc.date.issued 2021-01-25
dc.identifier.uri http://hdl.handle.net/10061/14220
dc.description.abstract Senescent cells, which show the permanent growth arrest in response to various forms of stress, accumulate in the body with the progression of age, and are associated with aging and age-associated diseases. Although the senescent cells are growth arrested, they still demonstrate high metabolic rate and altered gene expressions, indicating that senescent cells are still active. We recently showed that the circadian clock properties, namely phase and period of the cells, are altered with the establishment of replicative senescence. However, whether cellular senescence triggers the alteration of circadian clock properties in the cells is still unknown. In this study we show that the oxidative stress-induced premature senescence induces the alterations of the circadian clock, similar to the phenotypes of the replicative senescent cells. We found that the oxidative stress-induced premature senescent cells display the prolonged period and delayed phases. In addition, the magnitude of these changes intensified over time, indicating that cellular senescence changes the circadian clock properties. Our current results corroborate with our previous findings and further confirm that cellular senescence induces altered circadian clock properties, irrespective of the replicative senescence or the stress-induced premature senescence. ja_JP
dc.language.iso en ja_JP
dc.publisher Frontiers Media ja_JP
dc.relation.isreplacedby https://www.frontiersin.org/articles/10.3389/fnins.2021.638122/full ja_JP
dc.rights © 2021 Ahmed, Nakahata, Shinohara and Bessho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. ja_JP
dc.subject circadian ja_JP
dc.subject clock ja_JP
dc.subject senescence ja_JP
dc.subject aging ja_JP
dc.subject oxidative stress ja_JP
dc.title Cellular Senescence Triggers Altered Circadian Clocks With a Prolonged Period and Delayed Phases ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription ナカハタ, ヤスカズ
dc.contributor.transcription ベッショ, ヤスマサ
dc.contributor.alternative 中畑, 泰和
dc.contributor.alternative 別所, 康全
dc.textversion none ja_JP
dc.identifier.eissn 1662-453X
dc.identifier.jtitle Frontiers in Neuroscience ja_JP
dc.relation.doi 10.3389/fnins.2021.638122 ja_JP
dc.identifier.NAIST-ID 73290710 ja_JP
dc.identifier.NAIST-ID 73290454 ja_JP

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