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Area cooling enables thermal positioning and manipulation of single cellls

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dc.contributor.author Shen, Yigang
dc.contributor.author Yalikun, Yaxiaer
dc.contributor.author Aishan, Yusufu
dc.contributor.author Tanaka, Nobuyuki
dc.contributor.author Sato, Asako
dc.contributor.author Tanaka, Yo
dc.date.accessioned 2020-12-04T09:09:57Z
dc.date.available 2020-12-04T09:09:57Z
dc.date.issued 2020-10-01
dc.identifier.uri http://hdl.handle.net/10061/14166
dc.description.abstract Contactless particle manipulation based on a thermal field has shown great potential for biological, medical, and materials science applications. However, thermal diffusion from a high-temperature area causes thermal damage to bio-samples. Besides, the permanent bonding of a sample chamber onto microheater substrates requires that the thermal field devices be non-disposable. These limitations impede use of the thermal manipulation approach. Here, a novel manipulation platform is proposed that combines microheaters and an area cooling system to produce enough force to steer sedimentary particles or cells and to limit the thermal diffusion. It uses the one-time fabricated motherboard and an exchangeable sample chamber that provides disposable use. Sedimentary objects can be steered to the bottom center of the thermal field by combined thermal convection and thermophoresis. Single particle or cell manipulation is realized by applying multiple microheaters in the platform. Results of a cell viability test confirmed the method's compatibility in biology fields. With its advantages of biocompatibility for live cells, operability for different sizes of particles and flexibility of platform fabrication, this novel manipulation platform has a high potential to become a powerful tool for biology research. ja_JP
dc.language.iso en ja_JP
dc.publisher Royal Society of Chemistry ja_JP
dc.relation.isreplacedby https://pubs.rsc.org/en/content/articlelanding/2020/LC/D0LC00523A#!divAbstract ja_JP
dc.rights This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. ja_JP
dc.title Area cooling enables thermal positioning and manipulation of single cellls ja_JP
dc.type.nii Journal Article ja_JP
dc.textversion none ja_JP
dc.identifier.eissn 1473-0189
dc.identifier.jtitle Lab on a Chip ja_JP
dc.identifier.issue 20 ja_JP
dc.relation.doi 10.1039/d0lc00523a ja_JP
dc.identifier.NAIST-ID 74654880 ja_JP


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