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Celf1 is required for formation of endoderm-derived organs in zebrafish

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dc.contributor.author Tahara, Naoyuki
dc.contributor.author Bessho, Yasumasa
dc.contributor.author Matsui, Takaaki
dc.date.accessioned 2020-11-24T04:25:41Z
dc.date.available 2020-11-24T04:25:41Z
dc.date.issued 2013-09-03
dc.identifier.uri http://hdl.handle.net/10061/14153
dc.description.abstract We recently reported that an RNA binding protein called Cugbp Elav-like family member 1 (Celf1) regulates somite symmetry and left-right patterning in zebrafish. In this report, we show additional roles of Celf1 in zebrafish organogenesis. When celf1 is knocked down by using an antisense morpholino oligonucleotides (MO), liver buds fail to form, and pancreas buds do not form a cluster, suggesting earlier defects in endoderm organogenesis. As expected, we found failures in endoderm cell growth and migration during gastrulation in embryos injected with celf1-MOs. RNA immunoprecipitation revealed that Celf1 binds to gata5 and cdc42 mRNAs which are known to be involved in cell growth and migration, respectively. Our results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets. ja_JP
dc.language.iso en ja_JP
dc.publisher MDPI ja_JP
dc.relation.isreplacedby https://www.mdpi.com/1422-0067/14/9/18009 ja_JP
dc.rights © 2013 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). ja_JP
dc.subject post-transcriptional regulation ja_JP
dc.subject endoderm ja_JP
dc.subject liver ja_JP
dc.subject pancreas ja_JP
dc.subject movement ja_JP
dc.subject proliferation ja_JP
dc.title Celf1 is required for formation of endoderm-derived organs in zebrafish ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription ベッショ, ヤスマサ
dc.contributor.transcription マツイ, タカアキ
dc.contributor.alternative 別所, 康全
dc.contributor.alternative 松井, 貴輝
dc.textversion publisher ja_JP
dc.identifier.eissn 1422-0067
dc.identifier.jtitle International Journal of Molecular Sciences ja_JP
dc.identifier.volume 14 ja_JP
dc.identifier.issue 9 ja_JP
dc.identifier.spage 18009 ja_JP
dc.identifier.epage 18023 ja_JP
dc.relation.doi 10.3390/ijms140918009 ja_JP
dc.identifier.NAIST-ID 73290454 ja_JP
dc.identifier.NAIST-ID 73290470 ja_JP

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