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Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

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dc.contributor.author Shiromizu, Takashi
dc.contributor.author Yuge, Mizuki
dc.contributor.author Kasahara, Kousuke
dc.contributor.author Yamakawa, Daishi
dc.contributor.author Matsui, Takaaki
dc.contributor.author Bessho, Yasumasa
dc.contributor.author Inagaki, Masaki
dc.contributor.author Nishimura, Yuhei
dc.date.accessioned 2020-09-23T07:14:00Z
dc.date.available 2020-09-23T07:14:00Z
dc.date.issued 2020-08-19
dc.identifier.uri http://hdl.handle.net/10061/14060
dc.description.abstract Cilia are antenna-like structures present in many vertebrate cells. These organelles detect extracellular cues, transduce signals into the cell, and play an essential role in ensuring correct cell proliferation, migration, and differentiation in a spatiotemporal manner. Not surprisingly, dysregulation of cilia can cause various diseases, including cancer and ciliopathies, which are complex disorders caused by mutations in genes regulating ciliary function. The structure and function of cilia are dynamically regulated through various mechanisms, among which E3 ubiquitin ligases and deubiquitinases play crucial roles. These enzymes regulate the degradation and stabilization of ciliary proteins through the ubiquitin–proteasome system. In this review, we briefly highlight the role of cilia in ciliopathy and cancer; describe the roles of E3 ubiquitin ligases and deubiquitinases in ciliogenesis, ciliopathy, and cancer; and highlight some of the E3 ubiquitin ligases and deubiquitinases that are potential therapeutic targets for these disorders. ja_JP
dc.language.iso en ja_JP
dc.publisher MDPI ja_JP
dc.relation.isreplacedby https://www.mdpi.com/1422-0067/21/17/5962 ja_JP
dc.rights © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). ja_JP
dc.subject ubiquitin–proteasome pathway ja_JP
dc.subject cilia ja_JP
dc.subject ciliogenesis ja_JP
dc.subject differentiation ja_JP
dc.subject proliferation; ja_JP
dc.subject ciliopathy ja_JP
dc.subject cancer ja_JP
dc.title Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription マツイ, タカアキ
dc.contributor.transcription ベッショ, ヤスマサ
dc.contributor.alternative 松井, 輝貴
dc.contributor.alternative 別所, 康全
dc.textversion none ja_JP
dc.identifier.eissn 1422-0067
dc.identifier.jtitle International Journal of Molecular Sciences ja_JP
dc.identifier.volume 21 ja_JP
dc.identifier.issue 17 ja_JP
dc.relation.doi 10.3390/ijms21175962 ja_JP
dc.identifier.NAIST-ID 73290470 ja_JP
dc.identifier.NAIST-ID 73290454 ja_JP

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