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Forces to Drive Neuronal Migration Steps

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dc.contributor.author Minegishi, Takunori
dc.contributor.author Inagaki, Naoyuki
dc.date.accessioned 2020-09-18T10:41:10Z
dc.date.available 2020-09-18T10:41:10Z
dc.date.issued 2020-09-01
dc.identifier.uri http://hdl.handle.net/10061/14058
dc.description.abstract To establish and maintain proper brain architecture and elaborate neural networks, neurons undergo massive migration. As a unique feature of their migration, neurons move in a saltatory manner by repeating two distinct steps: extension of the leading process and translocation of the cell body. Neurons must therefore generate forces to extend the leading process as well as to translocate the cell body. In addition, neurons need to switch these forces alternately in order to orchestrate their saltatory movement. Recent studies with mechanobiological analyses, including traction force microscopy, cell detachment analyses, live-cell imaging, and loss-of-function analyses, have begun to reveal the forces required for these steps and the molecular mechanics underlying them. Spatiotemporally organized forces produced between cells and their extracellular environment, as well as forces produced within cells, play pivotal roles to drive these neuronal migration steps. Traction force produced by the leading process growth cone extends the leading processes. On the other hand, mechanical tension of the leading process, together with reduction in the adhesion force at the rear and the forces to drive nucleokinesis, translocates the cell body. Traction forces are generated by mechanical coupling between actin filament retrograde flow and the extracellular environment through clutch and adhesion molecules. Forces generated by actomyosin and dynein contribute to the nucleokinesis. In addition to the forces generated in cell-intrinsic manners, external forces provided by neighboring migratory cells coordinate cell movement during collective migration. Here, we review our current understanding of the forces that drive neuronal migration steps and describe the molecular machineries that generate these forces for neuronal migration. ja_JP
dc.language.iso en ja_JP
dc.publisher Frontiers Media ja_JP
dc.relation.isreplacedby https://www.frontiersin.org/articles/10.3389/fcell.2020.00863/full ja_JP
dc.rights Copyright © 2020 Minegishi and Inagaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ja_JP
dc.subject neuronal migration ja_JP
dc.subject mechanobiology ja_JP
dc.subject traction force ja_JP
dc.subject adhesion force ja_JP
dc.subject mechanical tension ja_JP
dc.subject shootin1 ja_JP
dc.subject actomyosin ja_JP
dc.subject dynein ja_JP
dc.title Forces to Drive Neuronal Migration Steps ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription ミネギシ, タクノリ
dc.contributor.transcription イナガキ, ナオユキ
dc.contributor.alternative 嶺岸, 卓德
dc.contributor.alternative 稲垣, 直之
dc.textversion none ja_JP
dc.identifier.eissn 2296-634X
dc.identifier.jtitle Frontiers in Cell and Developmental Biology ja_JP
dc.relation.doi 10.3389/fcell.2020.00863 ja_JP
dc.identifier.NAIST-ID 83519249 ja_JP
dc.identifier.NAIST-ID 73290314 ja_JP

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