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Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice

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dc.contributor.author Oji, Asami
dc.contributor.author Isotani, Ayako
dc.contributor.author Fujihara, Yoshitaka
dc.contributor.author Castaneda, Julio M
dc.contributor.author Oura, Seiya
dc.contributor.author Ikawa, Masahito
dc.date.accessioned 2020-08-25T02:10:06Z
dc.date.available 2020-08-25T02:10:06Z
dc.date.issued 2020-04-15
dc.identifier.uri http://hdl.handle.net/10061/14028
dc.description.abstract In mammals, more than 2000 genes are specifically or abundantly expressed in testis, but gene knockout studies revealed several are not individually essential for male fertility. Tesmin (Metallothionein-like 5; Mtl5) was originally reported as a testis-specific transcript that encodes a member of the cysteine-rich motif containing metallothionein family. Later studies showed that Tesmin has two splicing variants and both are specifically expressed in male and female germ cells. Herein, we clarified that the long (Tesmin-L) and short (Tesmin-S) transcript forms start expressing from spermatogonia and the spermatocyte stage, respectively, in testis. Furthermore, while Tesmin-deficient female mice are fertile, male mice are infertile due to arrested spermatogenesis at the pachytene stage. We were able to rescue the infertility with a Tesmin-L transgene, where we concluded that TESMIN-L is critical for meiotic completion in spermatogenesis and indispensable for male fertility. ja_JP
dc.language.iso en ja_JP
dc.publisher Oxford University Press ja_JP
dc.relation.isreplacedby https://academic.oup.com/biolreprod/article/102/4/975/5698627 ja_JP
dc.rights © The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. ja_JP
dc.subject knockout ja_JP
dc.subject male infertility ja_JP
dc.subject meiotic arrest ja_JP
dc.subject spermatogenesis ja_JP
dc.title Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription イソタニ, アヤコ
dc.contributor.alternative 磯谷, 綾子
dc.textversion none ja_JP
dc.identifier.eissn 1529-7268
dc.identifier.jtitle Biology of Reproduction ja_JP
dc.identifier.volume 102 ja_JP
dc.identifier.issue 4 ja_JP
dc.identifier.spage 975 ja_JP
dc.identifier.epage 983 ja_JP
dc.relation.doi 10.1093/biolre/ioaa002 ja_JP
dc.identifier.NAIST-ID 74653114 ja_JP
dc.relation.pmid 31916570 ja_JP


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