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PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond

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dc.contributor.author Ishida, Yasumasa en
dc.date.accessioned 2020-08-06T06:34:53Z en
dc.date.available 2020-08-06T06:34:53Z en
dc.date.issued 2020-06-01 en
dc.identifier.uri http://hdl.handle.net/10061/14015 en
dc.description.abstract On December 10, 2018, I was sitting among the big crowd of audience, as one of the invited guests to the ceremony, in the Stockholm Concert Hall. When King of Sweden Carl XVI Gustaf bestowed the diploma and medal of Nobel Prize of Physiology or Medicine 2018 on Dr. Tasuku Honjo and shook his hand for a while, surrounded by the thunderous applause and energetically blessing orchestral music, I thought that it had been a long journey for the molecule that we had first isolated in the early 1990s. Although it was truly a commemorable moment in the history of the programmed death-1 (PD-1) research, I believe we still have a long way to go. In this review article, I will explain why I think so, particularly by focusing on the potential role(s) that PD-1 appears to play in self-nonself discrimination by the immune system. en
dc.language.iso en en
dc.publisher MDPI en
dc.rights © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license(http://creativecommons.org/licenses/by/4.0/). ja
dc.subject PD-1 en
dc.subject T cell en
dc.subject subtractive hybridization en
dc.subject self-nonself discrimination en
dc.subject cancer en
dc.subject immunotherapy en
dc.title PD-1: Its Discovery, Involvement in Cancer Immunotherapy, and Beyond en
dc.type.nii Journal Article en
dc.contributor.transcription イシダ, ヤスマサ ja
dc.contributor.alternative 石田, 靖雅 ja
dc.textversion publisher en
dc.identifier.eissn 2073-4409 en
dc.identifier.jtitle Cells en
dc.relation.doi 10.3390/cells9061376 en
dc.identifier.NAIST-ID 73290355 en

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