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Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system

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dc.contributor.author Urasaki, Akihiro en
dc.contributor.author Morishita, Seiya en
dc.contributor.author Naka, Kosuke en
dc.contributor.author Uozumi, Minato en
dc.contributor.author Abe, Kouki en
dc.contributor.author Huang, Liguo en
dc.contributor.author Watase, Emiko en
dc.contributor.author Nakagawa, Osamu en
dc.contributor.author Kawakami, Koichi en
dc.contributor.author Matsui, Takaaki en
dc.contributor.author Bessho, Yasumasa en
dc.contributor.author Inagaki, Naoyuki en
dc.date.accessioned 2019-08-27T01:53:14Z en
dc.date.available 2019-08-27T01:53:14Z en
dc.date.issued 2019-08-21 en
dc.identifier.issn 2045-2322 en
dc.identifier.uri http://hdl.handle.net/10061/13362 en
dc.description.abstract The zebrafish sensory posterior lateral line is an excellent model system to study collective cell migration and organogenesis. Shootin1 is a cytoplasmic protein involved in neuronal polarization and axon guidance. Previous studies have shown that shootin1 couples actin filament retrograde flow with extracellular adhesive substrates at the leading edge of axonal growth cones, thereby producing mechanical force for the migration and guidance of axonal growth cones. However, the functions of shootin in peripheral cells remain unknown. Here we identified two novel shootin family members, shootin2 and shootin3. In zebrafish, shootin1 and shootin3 are expressed in the posterior lateral line primordium (PLLP) and neuromasts during embryonic development. A shootin1 mutant displayed a reduced speed of PLLP migration, while shootin1;shootin3 double mutation inhibited cell proliferation in the PLLP. Furthermore, our results suggest that shootin1 and shootin3 positively regulate the number of neuromasts and the number of cells in deposited neuromasts. Our study demonstrates that shootins mediate collective cell migration of the posterior lateral line primordium and formation of neuromasts in zebrafish. en
dc.language.iso en en
dc.publisher Springer Nature en
dc.relation.isreplacedby https://www.nature.com/articles/s41598-019-48585-4 en
dc.rights Copyright © 2019, Springer Nature ja
dc.title Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system en
dc.type.nii Journal Article en
dc.contributor.transcription マツイ, タカアキ ja
dc.contributor.transcription ベッショ, ヤスマサ ja
dc.contributor.transcription イナガキ, ナオユキ ja
dc.contributor.alternative 松井, 貴輝 ja
dc.contributor.alternative 別所, 康全 ja
dc.contributor.alternative 稲垣, 直之 ja
dc.textversion publisher en
dc.identifier.jtitle Scientific Reports en
dc.identifier.volume 9 en
dc.relation.doi 10.1038/s41598-019-48585-4 en
dc.identifier.artnum 12156 (2019) en
dc.identifier.NAIST-ID 73290470 en
dc.identifier.NAIST-ID 73290454 en
dc.identifier.NAIST-ID 73290314 en


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