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A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

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dc.contributor.author Takahashi, Naoki en
dc.contributor.author Ogita, Nobuo en
dc.contributor.author Takahashi, Tomonobu en
dc.contributor.author Taniguchi, Shoji en
dc.contributor.author Tanaka, Maho en
dc.contributor.author Seki, Motoaki en
dc.contributor.author Umeda, Masaaki en
dc.date.accessioned 2019-04-11T02:05:52Z en
dc.date.available 2019-04-11T02:05:52Z en
dc.date.issued 2019-04-04 en
dc.identifier.other 2050-084X en
dc.identifier.uri http://hdl.handle.net/10061/13132 en
dc.description.abstract Cell cycle arrest is an active response to stresses that enables organisms to survive under fluctuating environmental conditions. While signalling pathways that inhibit cell cycle progression have been elucidated, the putative core module orchestrating cell cycle arrest in response to various stresses is still elusive. Here we report that in Arabidopsis, the NAC-type transcription factors ANAC044 and ANAC085 are required for DNA damage-induced G2 arrest. Under genotoxic stress conditions, ANAC044 and ANAC085 enhance protein accumulation of the R1R2R3-type Myb transcription factor (Rep-MYB), which represses G2/M-specific genes. ANAC044/ANAC085-dependent accumulation of Rep-MYB and cell cycle arrest are also observed in the response to heat stress that causes G2 arrest, but not to osmotic stress that retards G1 progression. These results suggest that plants deploy the ANAC044/ANAC085-mediated signalling module as a hub which perceives distinct stress signals and leads to G2 arrest. en
dc.language.iso en en
dc.publisher eLife Sciences Publications, Ltd en
dc.rights © 2019, Takahashi et al. ja
dc.rights This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. en
dc.subject cell cycle arrest en
dc.subject DNA damage en
dc.subject heat stress en
dc.subject transcription factors en
dc.subject protein stability en
dc.subject gene expression en
dc.title A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis en
dc.type.nii Journal Article en
dc.contributor.transcription タカハシ, ナオキ ja
dc.contributor.transcription オギタ, ノブオ ja
dc.contributor.transcription タカハシ, トモノブ ja
dc.contributor.transcription タニグチ, ショウジ ja
dc.contributor.transcription タナカ, マホ ja
dc.contributor.transcription セキ, モトアキ ja
dc.contributor.transcription ウメダ, マサアキ ja
dc.contributor.alternative 高橋, 直紀 ja
dc.contributor.alternative 荻田, 伸夫 ja
dc.contributor.alternative 高橋, 知伸 ja
dc.contributor.alternative 谷口, 昌司 ja
dc.contributor.alternative 田中, 真帆 ja
dc.contributor.alternative 関, 原明 ja
dc.contributor.alternative 梅田, 正明 ja
dc.textversion publisher en
dc.identifier.jtitle eLife en
dc.identifier.volume 8 en
dc.relation.doi 10.7554/eLife.43944 en
dc.identifier.artnum e43944 en
dc.identifier.NAIST-ID 73294654 en
dc.identifier.NAIST-ID 83515221 en
dc.identifier.NAIST-ID 85628030 en
dc.identifier.NAIST-ID 85628089 en
dc.identifier.NAIST-ID 73290587 en
dc.relation.pmid 30944065 en


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