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Remote Coupled Drastic β-Barrel to β-Sheet Transition of the Protein Translocation Motor

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dc.contributor.author Arata, Furukawa en
dc.contributor.author Nakayama, Shintaro en
dc.contributor.author Yoshikaie, Kunihito en
dc.contributor.author Tanaka, Yoshiki en
dc.contributor.author Tsukazaki, Tomoya en
dc.date.accessioned 2018-03-07T06:58:29Z en
dc.date.available 2018-03-07T06:58:29Z en
dc.date.issued 2018-02-01 en
dc.identifier.issn 0969-2126 en
dc.identifier.uri http://hdl.handle.net/10061/12212 en
dc.description.abstract Summary The membrane protein SecDF, belonging to the RND superfamily, enhances protein translocation at the extracytoplasmic side using a proton gradient. Here, we report the crystal structure of SecDF in a form we named Super-membrane-facing (Super F) form, demonstrating a β-barrel architecture instead of the previously reported β-sheet structure. Through this structural insight and supporting results of an in vivo crosslinking experiment, we propose a remote coupling model in which a structural change of the transmembrane region drives a functional, extracytoplasmic conformational transition. ja
dc.language.iso en en
dc.publisher Elsevier en
dc.rights © 2018 Elsevier Ltd. ja
dc.rights 出版者許諾条件により、本文は2019年2月1日以降公開。 ja
dc.subject remote coupling en
dc.subject membrane protein en
dc.subject motor en
dc.subject crystal structure en
dc.subject conformational transition en
dc.subject protein translocation en
dc.subject secretion en
dc.subject SecDF en
dc.subject RND en
dc.title Remote Coupled Drastic β-Barrel to β-Sheet Transition of the Protein Translocation Motor ja
dc.type.nii Journal Article en
dc.contributor.transcription フルカワ, アラタ ja
dc.contributor.transcription ナカヤマ, シンタロウ ja
dc.contributor.transcription ヨシカイエ, クニヒト ja
dc.contributor.transcription タナカ, ヨシキ ja
dc.contributor.transcription ツカザキ, トモヤ ja
dc.contributor.alternative 古川, 新 ja
dc.contributor.alternative 中山, 慎太郎 ja
dc.contributor.alternative 吉海江, 国仁 ja
dc.contributor.alternative 田中, 良樹 ja
dc.contributor.alternative 塚崎, 智也 ja
dc.textversion author en
dc.identifier.jtitle Structure en
dc.identifier.volume 26 en
dc.identifier.issue 3 en
dc.identifier.spage 485 en
dc.identifier.epage 489.e2 en
dc.relation.doi 10.1016/j.str.2018.01.002 en
dc.identifier.NAIST-ID 83519124 en
dc.identifier.NAIST-ID 85622538 en
dc.identifier.NAIST-ID 74651480 en
dc.identifier.NAIST-ID 74650169 en
dc.identifier.NAIST-ID 73299737 en
dc.relation.pmid 29398525 en

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