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The protein network of bacterial motility

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dc.contributor.author Rajagopala, Seesandra V en
dc.contributor.author Titz, Bjorn en
dc.contributor.author Goll, Johannes en
dc.contributor.author Parrish, Jodi R en
dc.contributor.author Wohlbold, Katrin en
dc.contributor.author McKevitt, Matthew T en
dc.contributor.author Palzkill, Timothy en
dc.contributor.author Mori, Hirotada en
dc.contributor.author Finley, Russell L en
dc.contributor.author Uetz, Peter en
dc.date.accessioned 2016-08-19T07:43:51Z en
dc.date.available 2016-08-19T07:43:51Z en
dc.date.issued 2007-07-31 en
dc.identifier.issn 1744-4292 en
dc.identifier.uri http://hdl.handle.net/10061/10974 en
dc.description.abstract Motility is achieved in most bacterial species by the flagellar apparatus. It consists of dozens of different proteins with thousands of individual subunits. The published literature about bacterial chemotaxis and flagella documented 51 protein?protein interactions (PPIs) so far. We have screened whole genome two‐hybrid arrays of Treponema pallidum and Campylobacter jejuni for PPIs involving known flagellar proteins and recovered 176 and 140 high‐confidence interactions involving 110 and 133 proteins, respectively. To explore the biological relevance of these interactions, we tested an Escherichia coli gene deletion array for motility defects (using swarming assays) and found 159 gene deletion strains to have reduced or no motility. Comparing our interaction data with motility phenotypes from E. coli, Bacillus subtilis, and Helicobacter pylori, we found 23 hitherto uncharacterized proteins involved in motility. Integration of phylogenetic information with our interaction and phenotyping data reveals a conserved core of motility proteins, which appear to have recruited many additional species‐specific components over time. Our interaction data also predict 18 110 interactions for 64 flagellated bacteria.Mol Syst Biol. 3: 128 ja
dc.language.iso en en
dc.publisher Nature Publishing Group en
dc.rights c 2007 EMBO and Nature Publishing Group en
dc.title The protein network of bacterial motility en
dc.type.nii Journal Article en
dc.contributor.transcription モリ, ヒロタダ ja
dc.contributor.alternative 森, 浩禎 ja
dc.textversion Publisher en
dc.identifier.jtitle Molecular Systems Biology en
dc.identifier.volume 3 en
dc.identifier.issue 1 en
dc.relation.doi 10.1038/msb4100166 en
dc.identifier.artnum 128 en
dc.identifier.NAIST-ID 73290108 en
dc.relation.pmid 17667950 en


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