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Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization

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dc.contributor.author Toriyama, Michinori en
dc.contributor.author Shimada, Tadayuki en
dc.contributor.author Kim, Ki Bum en
dc.contributor.author Mitsuba, Mari en
dc.contributor.author Nomura, Eiko en
dc.contributor.author Katsuta, Kazuhiro en
dc.contributor.author Sakumura, Yuichi en
dc.contributor.author Roepstorff, Peter en
dc.contributor.author Inagaki, Naoyuki en
dc.date.accessioned 2016-07-27T02:44:56Z en
dc.date.available 2016-07-27T02:44:56Z en
dc.date.issued 2006-10-09 en
dc.identifier.issn 1540-8140 en
dc.identifier.uri http://hdl.handle.net/10061/10673 en
dc.description.abstract Neurons have the remarkable ability to polarize even in symmetrical in vitro environments. Although recent studies have shown that asymmetric intracellular signals can induce neuronal polarization, it remains unclear how these polarized signals are organized without asymmetric cues. We describe a novel protein, named shootin1, that became up-regulated during polarization of hippocampal neurons and began fluctuating accumulation among multiple neurites. Eventually, shootin1 accumulated asymmetrically in a single neurite, which led to axon induction for polarization. Disturbing the asymmetric organization of shootin1 by excess shootin1 disrupted polarization, whereas repressing shootin1 expression inhibited polarization. Overexpression and RNA interference data suggest that shootin1 is required for spatially localized phosphoinositide-3-kinase activity. Shootin1 was transported anterogradely to the growth cones and diffused back to the soma; inhibiting this transport prevented its asymmetric accumulation in neurons. We propose that shootin1 is involved in the generation of internal asymmetric signals required for neuronal polarization. en
dc.language.iso en en
dc.publisher The Rockefeller University Press en
dc.rights Copyright c 2006 by The Rockefeller University Press. en
dc.title Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization en
dc.type.nii Journal Article en
dc.contributor.transcription トリヤマ, ミチノリ ja
dc.contributor.transcription シマダ, タダユキ ja
dc.contributor.transcription サクムラ, ユイチ ja
dc.contributor.transcription イナガキ, ナオユキ ja
dc.contributor.alternative 鳥山, 道則 ja
dc.contributor.alternative 島田, 忠之 ja
dc.contributor.alternative 作村, 諭一 ja
dc.contributor.alternative 稲垣, 直之 ja
dc.textversion Publisher en
dc.identifier.ncid AA1203766X en
dc.identifier.jtitle The Journal of Cell Biology en
dc.identifier.volume 175 en
dc.identifier.issue 1 en
dc.identifier.spage 147 en
dc.identifier.epage 157 en
dc.relation.doi 10.1083/jcb.200604160 en
dc.identifier.NAIST-ID 73290314 en
dc.identifier.NAIST-ID 73297863 en
dc.identifier.NAIST-ID 73293813 en
dc.relation.pmid 17030985 en

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