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Please use this identifier to cite or link to this item: http://hdl.handle.net/10061/8567

Title: Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury
Authors: Masahiko Abematsu
Keita Tsujimura
Mariko Yamano
Michiko Saito
Kenji Kohno
Jun Kohyama
Masakazu Namihira
Setsuro Komiya
Kinichi Nakashima
Issue Date: Sep-2010
Publisher: American Society for Clinical Investigation
Journal Title: Journal of Clinical Investigation
Volume: 120
Issue: 9
Start page: 3255
End page: 3266
Abstract: The body's capacity to restore damaged neural networks in the injured CNS is severely limited. Although various treatment regimens can partially alleviate spinal cord injury (SCI), the mechanisms responsible for symptomatic improvement remain elusive. Here, using a mouse model of SCI, we have shown that transplantation of neural stem cells (NSCs) together with administration of valproic acid (VPA), a known antiepileptic and histone deacetylase inhibitor, dramatically enhanced the restoration of hind limb function. VPA treatment promoted the differentiation of transplanted NSCs into neurons rather than glial cells. Transsynaptic anterograde corticospinal tract tracing revealed that transplant-derived neurons reconstructed broken neuronal circuits, and electron microscopic analysis revealed that the transplant-derived neurons both received and sent synaptic connections to endogenous neurons. Ablation of the transplanted cells abolished the recovery of hind limb motor function, confirming that NSC transplantation directly contributed to restored motor function. These findings raise the possibility that epigenetic status in transplanted NSCs can be manipulated to provide effective treatment for SCI.
URI: http://hdl.handle.net/10061/8567
ISSN: 0021-9738
Rights: Copyright (C) 2010 American Society for Clinical Investigation.
Text Version: Publisher
Publisher DOI: 10.1172/JCI42957
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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