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Please use this identifier to cite or link to this item: http://hdl.handle.net/10061/8566

Title: BMP-induced REST regulates the establishment and maintenance of astrocytic identity
Authors: Jun Kohyama
Tsukasa Sanosaka
Akinori Tokunaga
Eriko Takatsuka
Keita Tsujimura
Hideyuki Okano
Kinichi Nakashima
Issue Date: Apr-2010
Publisher: Rockefeller University Press
Journal Title: The Journal of Cell Biology
Volume: 189
Issue: 1
Start page: 159
End page: 170
Abstract: Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation remains unclear. In the mammalian central nervous system, neurons, astrocytes, and oligodendrocytes are generated throughout life from common tripotent neural progenitor cells (NPCs). Bone morphogenetic proteins (BMPs) are well-known astrocyte-inducing cytokines. We show here that the expression of a transcriptional repressor, RE1 silencer of transcription (REST)/neuron-restrictive silencer factor (NRSF), is up-regulated and sustained by BMP signal activation in the course of astrocytic differentiation of NPCs, and restricts neuronal differentiation. We further show that, in differentiated astrocytes, endogenous REST/NRSF associates with various neuronal genes and that disruption of its function resulted in their derepression, thereby explaining how ectopic neuronal gene expression is prevented in cells with astrocytic traits. Collectively, our results suggest that REST/NRSF functions as a molecular regulator of the nonneuronal phenotype in astrocytes.
URI: http://hdl.handle.net/10061/8566
ISSN: 0021-9525
Rights: Copyright (C) 2010 Rockefeller University Press.
Text Version: Publisher
Publisher DOI: 10.1083/jcb.200908048
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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