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Title: IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes.
Authors: Jenny Hsieh
James B. Aimone
Brian K. Kaspar
Tomoko Kuwabara
Kinichi Nakashima
Fred H. Gage
Keywords: glia
neural stem cell
Issue Date: 5-Jan-2004
Publisher: Rockefeller University Press
Journal Title: The Journal of Cell Biology
Volume: 164
Issue: 1
Start page: 111
End page: 122
Abstract: Adult multipotent neural progenitor cells can differentiate into neurons, astrocytes, and oligodendrocytes in the mammalian central nervous system, but the molecular mechanisms that control their differentiation are not yet well understood. Insulin-like growth factor I (IGF-I) can promote the differentiation of cells already committed to an oligodendroglial lineage during development. However, it is unclear whether IGF-I affects multipotent neural progenitor cells. Here, we show that IGF-I stimulates the differentiation of multipotent adult rat hippocampus-derived neural progenitor cells into oligodendrocytes. Modeling analysis indicates that the actions of IGF-I are instructive. Oligodendrocyte differentiation by IGF-I appears to be mediated through an inhibition of bone morphogenetic protein signaling. Furthermore, overexpression of IGF-I in the hippocampus leads to an increase in oligodendrocyte markers. These data demonstrate the existence of a single molecule, IGF-I, that can influence the fate choice of multipotent adult neural progenitor cells to an oligodendroglial lineage.
ISSN: 0021-9525
Rights: Copyright (C) 2004 Rockefeller University Press.
Text Version: Publisher
Publisher DOI: 10.1083/jcb.200308101
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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