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Title: Enhanced gene activation by Notch and BMP signaling cross-talk.
Authors: Takumi Takizawa
Wataru Ochiai
Kinichi Nakashima
Tetsuya Taga
Issue Date: 1-Oct-2003
Publisher: Oxford University Press
Journal Title: Nucleic Acids Research
Volume: 31
Issue: 19
Start page: 5723
End page: 5731
Abstract: The signaling systems of Notch and bone morphogenetic protein (BMP) are highly conserved from flies to mammals and have been shown to be important in the development of multiple organs. For instance, in the fate determination of mouse neuroepithelial cells, Notch signaling plays a role in keeping the progenitors from differentiating into neurons. BMP is also known to inhibit neuronal differentiation. In this paper, we show that BMP2 enhances Notch-induced transcriptional activation of Hes-5 and Hesr-1 in mouse neuroepithelial cells. BMP2 stimulation, in addition to the introduction of the intracellular domain of Notch (NIC), resulted in enhanced activation of the Hes-5 gene promoter. RBP-Jκ binding to its target sequence is important not only for Notch signaling, but also for BMP2 signaling, to activate the Hes-5 gene promoter. Smad1, a Smad species that is activated by BMP2, barely interacted with NIC, but did form a complex with NIC in the simultaneous presence of the coactivators P/CAF and p300. Recruitment of p300 to the NIC-containing complex was facilitated by activated Smad1, which is suggested to contribute to BMP2-mediated enhancement of Notch-induced Hes-5 expression. These data suggest a novel functional cooperation between Notch signaling and BMP signaling.
ISSN: 0305-1048
Rights: Copyright (C) 2003 Oxford University Press.
Text Version: Publisher
Publisher DOI: 10.1093/nar/gkg778
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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