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Title: The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.
Authors: Toshihisa Hatta
Kenji Moriyama
Kinichi Nakashima
Tetsuya Taga
Hiroki Otani
Keywords: gp130
Leukemia inhibitory factor
Cerebral cortex
Exo utero development
Knock-out mouse
Issue Date: 1-Jul-2002
Publisher: Society for Neuroscience
Journal Title: Journal of Neuroscience
Volume: 22
Issue: 13
Start page: 5516
End page: 5524
Abstract: The role of gp130 in cerebral cortical histogenesis remains unknown. Mice lacking gp130 showed a hypoplastic cortical plate and decreased incorporation of 5-bromo-2'-deoxyuridine (BrdU) in progenitor cells of the developing cerebrum. In contrast, injection of leukemia inhibitory factor (LIF), a gp130 ligand, into the lateral cerebral ventricle of wild-type embryos exo utero induced hyperplasia of the cerebral cortex and increased the incorporation of BrdU in progenitor cells. Furthermore, chronologically controlled injection of LIF followed or preceded by BrdU revealed that gp130-mediated signals promote the progenitor cells to reenter the stem cell cycle without affecting the duration of cell cycle and enhance the migration of postmitotic neurons in the developing cerebrum.
ISSN: 0270-6474
Rights: Copyright (C) 2002 Society for Neuroscience.
Text Version: Publisher
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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