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Title: Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation.
Authors: Kinichi Nakashima
Stefan Wiese
Makoto Yanagisawa
Hirokazu Arakawa
Naoki Kimura
Tatsuhiro Hisatsune
Kanji Yoshida
Tadamitsu Kishimoto
Michael Sendtner
Tetsuya Taga
Keywords: gp130
deficient mice
motor neuron
sensory neuron
Issue Date: 1-Jul-1999
Publisher: Society for Neuroscience
Journal Title: Journal of Neuroscience
Volume: 19
Issue: 13
Start page: 5429
End page: 5434
Abstract: gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130-deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 ?/? mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 ?/? mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytesin vivo.
ISSN: 0270-6474
Rights: Copyright (C) 1999 Society for Neuroscience.
Text Version: Publisher
Appears in Collections:バイオサイエンス研究科 / Graduate School of Biological Sciences

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