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学術雑誌論文 / Journal Article >
バイオサイエンス研究科 / Graduate School of Biological Sciences >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10061/6335
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| Title: | The period of the somite segmentation clock is sensitive to Notch activity |
| Authors: | Kim, Woong
Matsui, Takaaki
Yamao, Masataka
Ishibashi, Makoto
Tamada, Kota
Takumi, Toru
Kohno, Kenji
Oba, Shigeyuki
Ishii, Shin
Sakumura, Yuichi
Bessho, Yasumasa |
| Issue Date: | 27-Jul-2011 |
| Publisher: | American Society for Cell Biology |
| Journal Title: | MOLECULAR BIOLOGY OF THE CELL |
| Volume: | 22 |
| Issue: | 18 |
| Start page: | 3541 |
| End page: | 3549 |
| Abstract: | The number of vertebrae is defined strictly for a given species, and depends on the number of somites, which are the earliest metameric structures that form in development. Somites are formed by sequential segmentation. The periodicity of somite segmentation is orchestrated by the synchronous oscillation of gene expression in the presomitic mesoderm (PSM), termed the somite segmentation clock in which Notch signaling plays a crucial role. Here, we show that the clock period is sensitive to Notch activity, which is fine-tuned by its feedback regulator, Notch-regulated ankyrin repeat protein (Nrarp), and that Nrarp is essential for forming the proper number and morphology of axial skeleton components. Null-mutant mice for Nrarp have fewer vertebrae and have defective morphologies. Notch activity is enhanced in the PSM of the Nrarp-/- embryo, where the ~2-h segmentation period is extended by five minutes, thereby forming fewer somites and their resultant vertebrae. Reduced Notch activity partially rescues the Nrarp-/- phenotype in the number of somites, but not in morphology. Therefore we propose that the period of the somite segmentation clock is sensitive to Notch activity, and that Nrarp plays essential roles in the morphology of vertebrae and ribs. |
| URI: | http://hdl.handle.net/10061/6335 |
| ISSN: | 1059-1524 |
| Rights: | Copyright (C) 2011 American Society for Cell Biology. |
| Text Version: | author |
| Publisher DOI: | 10.1091/mbc.E11-02-0139 |
| Appears in Collections: | バイオサイエンス研究科 / Graduate School of Biological Sciences
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