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公開日 のブラウズ: バイオサイエンス研究科 / Graduate School of Biological Sciences

公開日 のブラウズ: バイオサイエンス研究科 / Graduate School of Biological Sciences

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  • Takpho, Natthaporn; Watanabe, Daisuke; Takagi, Hiroshi (Elsevier, 2018-03-19)
    Valine, which is one of the branched-chain amino acids (BCAAs) essential for humans, is widely used in animal feed, dietary supplements and pharmaceuticals. At the commercial level, valine is usually produced by bacterial ...
  • Yamada, Tatsuya; Nishiyama, Makoto; Oba, Shigeyuki; Jimbo, Henri Claver; Ikeda, Kazushi; Ishii, Shin; Hong, Kyonsoo; Sakumura, Yuichi (Nature Publishing Group, 2018-03-14)
    Biological cells express intracellular biomolecular information to the extracellular environment as various physical responses. We show a novel computational approach to estimate intracellular biomolecular pathways from ...
  • Abe, Kouki; Katsuno, Hiroko; Toriyama, Michinori; Baba, Kentarou; Mori, Tomoyuki; Hakoshima, Toshio; Kanemura, Yonehiro; Watanabe, Rikiya Watanabe; Inagaki, Naoyuki (National Academy of Sciences, 2018-02-26)
    Chemical cues presented on the adhesive substrate direct cell migration, a process termed haptotaxis. To migrate, cells must generate traction forces upon the substrate. However, how cells probe substrate-bound cues and ...
  • Ogita, Nobuo; Okushima, Yoko; Tokizawa, Mutsutomo; Yamamoto, Yoshiharu Y.; Tanaka, Maho; Seki, Motoaki; Makita, Yuko; Matsui, Minami; Okamoto Yoshiyama, Kaoru; Sakamoto, Tomoaki; Kurata, Tetsuya; Hiruma, Kei; Saijo, Yusuke; Takahashi, Naoki; Umeda, Masaaki (Wiley Online Library, 2018-02-11)
    In mammalian cells, the transcription factor p53 plays a crucial role in transmitting DNA damage signals to maintain genome integrity. However, in plants, orthologous genes for p53 and checkpoint proteins are absent. ...
  • Arata, Furukawa; Nakayama, Shintaro; Yoshikaie, Kunihito; Tanaka, Yoshiki; Tsukazaki, Tomoya (Elsevier, 2018-02-01)
    Summary The membrane protein SecDF, belonging to the RND superfamily, enhances protein translocation at the extracytoplasmic side using a proton gradient. Here, we report the crystal structure of SecDF in a form we named ...
  • Yamaguchi, Nobutoshi; Huang, Jiangbo; Xu, Yifeng; Tanoi, Keitaro; Ito, Toshiro (Springer Nature, 2017-10-24)
    To ensure successful plant reproduction and crop production, the spatial and temporal control of the termination of the floral meristem must be coordinated. In Arabidopsis, the timing of this termination is determined by ...
  • Daimon, Yasushi; Iwama-Masui, Chigusa; Tanaka, Yoshiki; Shiota, Takuya; Suzuki, Takehiro; Miyazaki, Ryoji; Sakurada, Hiroto; Lithgow, Trevor; Dohmae, Naoshi; Mori, Hiroyuki; Tsukazaki, Tomoya; Narita, Shin-ichiro; Akiyama, Yoshinori (John Wiley & Sons, Ltd, 2017-10-17)
    BepA (formerly YfgC) is an Escherichia coli periplasmic protein consisting of an N-terminal protease domain and a C-terminal tetratricopeptide repeat (TPR) domain. We have previously shown that BepA is a dual functional ...
  • Chen, Poyu; Takatsuka, Hirotomo; Takahashi, Naoki; Kurata, Rie; Fukao, Yoichiro; Kobayashi, Kosuke; Ito, Masaki; Umeda, Masaaki (Springer Nature, 2017-09-21)
    Inhibition of cell division is an active response to DNA damage that enables cells to maintain genome integrity. However, how DNA damage arrests the plant cell cycle is largely unknown. Here, we show that the repressor-type ...
  • Sugahara, Hirosuke; Okai, Shinsaku; Odamaki, Toshitaka; Wong, Chyn B; Kato, Kumiko; Mitsuyama, Eri; Xiao, Jin-Zhong; Shinkura, Reiko (Frontiers Media S.A., 2017-09-12)
    Gut microbiota is known to change with aging; however, the underlying mechanisms have not been well elucidated. Immunoglobulin A (IgA) is the dominant class of antibody secreted by the intestinal mucosa, and are thought ...
  • Chek, Min Fey; Kim, Sun-Yong; Mori, Tomoyuki; Arsad, Hasni; Samian, Mohammed Razip; Sudesh, Kumar; Hakoshima, Toshio (Macmillan Publishers Limited, part of Springer Nature., 2017-07-13)
    Polyhydroxyalkanoate (PHA) is a promising candidate for use as an alternative bioplastic to replace petroleum-based plastics. Our understanding of PHA synthase PhaC is poor due to the paucity of available three-dimensional ...
  • Ariga, Hirotaka; Katori, Taku; Tsuchimatsu, Takashi; Hirase, Taishi; Tajima, Yuri; Parker, Jane E; Alcazar, Ruben; Koornneef, Maarten; Hoekenga, Owen; Lipka, Alexander E.; Gore, Michael A.; Sakakibara, Hitoshi; Kojima, Mikiko; Kobayashi, Yuriko; Iuchi, Satoshi; Kobayashi, Masatomo; Shinozaki, Kazuo; Sakata, Yoichi; Hayashi, Takahisa; Saijo, Yusuke; Taji, Teruaki (2017-05-26)
    Osmotic stress caused by drought, salt or cold decreases plant fitness. Acquired stress tolerance defines the ability of plants to withstand stress following an initial exposure. We found previously that acquired osmotolerance ...
  • Kawasaki, Takumi; Ito, Kosuke; Miyata, Haruhiko; Akira, Shizuo; Kawai, Taro (EMBO Press, 2017-05-22)
    Alveolar macrophages (AMs) are specialized tissue‐resident macrophages that orchestrate the immune responses to inhaled pathogens and maintain organ homeostasis of the lung. Dysregulation of AMs is associated with allergic ...
  • Furukawa, Arata; Yoshikaie, Kunihito; Mori, Takaharu; Mori, Hiroyuki; Morimoto, Yusuke V; Sugano, Yasunori; Iwaki, Shigehiro; Minamino, Tohru; Sugita, Yuji; Tanaka, Yoshiki; Tsukazaki, Tomoya (Cell Press, 2017-05-02)
    Protein secretion mediated by SecYEG translocon and SecA ATPase is enhanced by membrane-embedded SecDF by using proton motive force. A previous structural study of SecDF indicated that it comprises 12 transmembrane helices ...
  • Tatebe, Hisashi; Murayama, Shinichi; Yonekura, Toshiya; Hatano, Tomoyuki; Richter, David; Furuya, Tomomi; Kataoka, Saori; Furuita, Kyoko; Kojima, Chojiro; Shiozaki, Kazuhiro; Sonenberg, Nahum (eLife Sciences Publications, Ltd, 2017-03-07)
    The target of rapamycin (TOR) protein kinase forms multi-subunit TOR complex 1 (TORC1) and TOR complex 2 (TORC2), which exhibit distinct substrate specificities. Sin1 is one of the TORC2-specific subunit essential for ...
  • Inagaki, Naoyuki; Katsuno, Hiroko (Cell Press, 2017-03-07)
    Actin filaments and associated proteins undergo wave-like movement in various cell types. Recent studies with cutting-edge analyses, including live-cell imaging, biophysical monitoring and manipulation, and mathematical ...
  • Kono, Takunari; Mehrotra, Sandhya; Endo, Chikako; Kizu, Natsuko; Matsuda, Mami; Kimura, Hiroyuki; Mizohata, Eiichi; Inoue, Tsuyoshi; Hasunuma, Tomohisa; Yokota, Akiho; Matsumura, Hiroyoshi; Ashida, Hiroki (Springer Nature, 2017-01-13)
    Two enzymes are considered to be unique to the photosynthetic Calvin–Benson cycle: ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), responsible for CO2 fixation, and phosphoribulokinase (PRK). Some archaea possess ...
  • Murase, Kohji; Shigenobu, Shuji; Fujii, Sota; Ueda, Kazuki; Murata, Takanori; Sakamoto, Ai; Wada, Yuko; Yamaguchi, Katsushi; Osakabe, Yuriko; Osakabe, Keishi; Kanno, Akira; Ozaki, Yukio; Takayama, Seiji (John Wiley & Sons, Inc., 2017-01-12)
    Dioecy is a plant mating system in which individuals of a species are either male or female. Although many flowering plants evolved independently from hermaphroditism to dioecy, the molecular mechanism underlying this ...
  • Davidson, Alice E; Liskova, Petra; Evans, Cerys J; Dudakova, Lubica; Noskova, Lenka; Pontikos, Nikolas; Hartmannova, Hana; Hodanova, Katerina; Stranecky, Viktor; Kozmik, Zbynek; Levis, Hannah J; Idigo, Nwamaka; Sasai, Noriaki; Maher, Geoffrey J; Bellingham, James; Veli, Neyme; Ebenezer, Neil D; Cheetham, Michael E; Daniels, Julie T; Thaung, Caroline M.H; Jirsova, Katerina; Plagnol, Vincent; Filipec, Martin; Kmoch, Stanislav; Tuft, Stephen J; Hardcastle, Alison J (Cell Press, 2017-01-07)
    Congenital hereditary endothelial dystrophy 1 (CHED1) and posterior polymorphous corneal dystrophy 1 (PPCD1) are autosomal-dominant corneal endothelial dystrophies that have been genetically mapped to overlapping loci on ...
  • Yasuda, Shinsuke; Wada, Yuko; Kakizaki, Tomohiro; Tarutani, Yoshiaki; Miura-Uno, Eiko; Murase, Kohji; Fujii, Sota; Hioki, Tomoya; Shimoda, Taiki; Takada, Yoshinobu; Shiba, Hiroshi; Takasaki-Yasuda, Takeshi; Suzuki, Go; Watanabe, Masao; Takayama, Seiji (Macmillan Publishers Limited, 2016-12-22)
    In diploid organisms, phenotypic traits are often biased by effects known as Mendelian dominant–recessive interactions between inherited alleles. Phenotypic expression of SP11 alleles, which encodes the male determinants ...
  • Yamada, Kohji; Saijo, Yusuke; Nakagami, Hirofumi; Takano, Yoshitaka (American Association for the Advancement of Science, 2016-11-24)
    Microbial pathogens strategically acquire metabolites from their hosts during infection. Here we show that the host can intervene to prevent such metabolite loss to pathogens. Phosphorylation-dependent regulation of sugar ...

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