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バイオサイエンス研究科 / Graduate School of Biological Sciences

バイオサイエンス研究科 / Graduate School of Biological Sciences

 

最新登録資料

  • Davidson, Alice E; Liskova, Petra; Evans, Cerys J; Dudakova, Lubica; Noskova, Lenka; Pontikos, Nikolas; Hartmannova, Hana; Hodanova, Katerina; Stranecky, Viktor; Kozmik, Zbynek; Levis, Hannah J; Idigo, Nwamaka; Sasai, Noriaki; Maher, Geoffrey J; Bellingham, James; Veli, Neyme; Ebenezer, Neil D; Cheetham, Michael E; Daniels, Julie T; Thaung, Caroline M.H; Jirsova, Katerina; Plagnol, Vincent; Filipec, Martin; Kmoch, Stanislav; Tuft, Stephen J; Hardcastle, Alison J (Cell Press, 2017-01-07)
    Congenital hereditary endothelial dystrophy 1 (CHED1) and posterior polymorphous corneal dystrophy 1 (PPCD1) are autosomal-dominant corneal endothelial dystrophies that have been genetically mapped to overlapping loci on ...
  • Kono, Takunari; Mehrotra, Sandhya; Endo, Chikako; Kizu, Natsuko; Matsuda, Mami; Kimura, Hiroyuki; Mizohata, Eiichi; Inoue, Tsuyoshi; Hasunuma, Tomohisa; Yokota, Akiho; Matsumura, Hiroyoshi; Ashida, Hiroki (Springer Nature, 2017-01-13)
    Two enzymes are considered to be unique to the photosynthetic Calvin–Benson cycle: ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), responsible for CO2 fixation, and phosphoribulokinase (PRK). Some archaea possess ...
  • Yasuda, Shinsuke; Wada, Yuko; Kakizaki, Tomohiro; Tarutani, Yoshiaki; Miura-Uno, Eiko; Murase, Kohji; Fujii, Sota; Hioki, Tomoya; Shimoda, Taiki; Takada, Yoshinobu; Shiba, Hiroshi; Takasaki-Yasuda, Takeshi; Suzuki, Go; Watanabe, Masao; Takayama, Seiji (Macmillan Publishers Limited, 2016-12-22)
    In diploid organisms, phenotypic traits are often biased by effects known as Mendelian dominant–recessive interactions between inherited alleles. Phenotypic expression of SP11 alleles, which encodes the male determinants ...
  • Yamada, Kohji; Saijo, Yusuke; Nakagami, Hirofumi; Takano, Yoshitaka (American Association for the Advancement of Science, 2016-11-24)
    Microbial pathogens strategically acquire metabolites from their hosts during infection. Here we show that the host can intervene to prevent such metabolite loss to pathogens. Phosphorylation-dependent regulation of sugar ...
  • Kamiya, Masako; Higashio, Shin-Ya; Isomoto, Atsushi; Kim, Jong-Myong; Seki, Motoaki; Miyashima, Shunsuke; Nakajima, Keiji (The Company of Biologists Ltd, 2016-11-01)
    The root cap supports root growth by protecting the root meristem, sensing gravity and interacting with the rhizosphere through metabolite secretion and cell dispersal. Sustained root cap functions therefore rely on balanced ...
  • Okubo-Kurihara, Emiko; Ohtani, Misato; Kurihara, Yukio; Kakegawa, Koichi; Kobayashi, Megumi; Nagata, Noriko; Komatsu, Takanori; Kikuchi, Jun; Cutler, Sean; Demura, Taku; Matsui, Minami (Macmillan Publishers Limited, part of Springer Nature, 2016-10-03)
    The cell wall is one major determinant of plant cell morphology, and is an attractive bioresource. Here, we report a novel strategy to modify plant cell wall property by small molecules. Lasalocid sodium (LS) was isolated ...
  • Kanda, Satoshi; Yanagitani, Kota; Yokota, Yukiko; Esaki, Yuta; Kohno, Kenji (National Academy of Sciences of the United States of America, 2016-09-20)
    Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress ...
  • Kitano, Ken (Frontiers Media, 2014-10-29)
    The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic ...
  • 北野, 健 (日本結晶学会, 2015-05-01)
    The RecQ family of DNA helicases play a key role in protecting the genome against deleterious changes. In humans, mutations in the members WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) respectively lead ...
  • 北野, 健 (日本生物物理学会, 2014-09-30)
  • Kim, Sun-Yong; Hakoshima, Toshio; Kitano, Ken (Nature Publishing Group, 2013-11-21)
    Bloom syndrome is a rare genetic disorder characterized by genomic instability and cancer predisposition. The disease is caused by mutations of the Bloom syndrome protein (BLM). Here we report the crystal structure of a ...
  • Kim, Sun-Yong; Tachioka, Yuka; Mori, Tomoyuki; Hakoshima, Toshio (Nature Publishing Group, 2016-06-23)
    MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. MOB1 is present in an autoinhibited form and is activated by MST1/2-mediated phosphorylation, although the precise ...
  • Montero, Manuel; Rahimpour, Mehdi; Viale, Alejandro M.; Almagro, Goizeder; Eydallin, Gustavo; Sevilla, Angel; Canovas, Manuel; Bernal, Cristina; Lozano, Ana Belen; Munoz, Francisco Jose; Baroja-Fernandez, Edurne; Bahaji, Abdellatif; Mori, Hirotada; Codoner, Francisco M.; Pozueta-Romero, Javier (Public Library of Science, 2014-09-04)
    In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function ...
  • Yamamoto, Tatsuo; Takano, Tomomi; Higuchi, Wataru; Iwao, Yasuhisa; Singur, Olga; Reva, Ivan; Otsuka, Yuta; Nakayashiki, Toru; Mori, Hirotada; Reva, Galina; Kuznetsov, Vladimir; Potapov, Vladimir (Public Library of Science, 2012-01-19)
    Two distinct classes of methicillin-resistant Staphylococcus aureus (MRSA) are spreading in hospitals (as hospital-acquired MRSA, HA-MRSA) and in the community (as community-acquired MRSA, CA-MRSA). Multilocus sequence ...
  • Aoki, Wataru; Saito, Masato; Manabe, Ri-ichiroh; Mori, Hirotada; Yamaguchi, Yoshinori; Tamiya, Eiichi (Nature Publishing Group, 2014-04-17)
    We propose ‘integrated synthetic genetics’ as a novel methodology that integrates reductive and synthetic approaches used in life science research. Integrated synthetic genetics enables determinations of sets of genes ...
  • Rajagopala, Seesandra V; Titz, Bjorn; Goll, Johannes; Parrish, Jodi R; Wohlbold, Katrin; McKevitt, Matthew T; Palzkill, Timothy; Mori, Hirotada; Finley, Russell L; Uetz, Peter (Nature Publishing Group, 2007-07-31)
    Motility is achieved in most bacterial species by the flagellar apparatus. It consists of dozens of different proteins with thousands of individual subunits. The published literature about bacterial chemotaxis and flagella ...
  • Usui, Yuki; Hirasawa, Takashi; Furusawa, Chikara; Shirai, Tomokazu; Yamamoto, Natsuko; Mori, Hirotada; Shimizu, Hiroshi (BioMed Central Ltd, 2012-06-21)
    It has long been recognized that analyzing the behaviour of the complex intracellular biological networks is important for breeding industrially useful microorganisms. However, because of the complexity of these biological ...
  • Tian, Zhongyuan; Faure, Adrien; Mori, Hirotada; Matsuno, Hiroshi (BioMed Central Ltd, 2013-12-13)
    Glycogen and glucose are two sugar sources available during the lag phase of E. coli, but the mechanism that regulates their utilization is still unclear.
  • Otsuka, Yuta; Muto, Ai; Takeuchi, Rikiya; Okada, Chihiro; Ishikawa, Motokazu; Nakamura, Koichiro; Yamamoto, Natsuko; Dose, Hitomi; Nakahigashi, Kenji; Tanishima, Shigeki; Suharnan, Sivasundaram; Nomura, Wataru; Nakayashiki, Toru; Aref, Walid G.; Bochner, Barry R.; Conway, Tyrrell; Gribskov, Michael; Kihara, Daisuke; Rudd, Kenneth E.; Tohsato, Yukako; Wanner, Barry L.; Mori, Hirotada (Oxford University Press, 2015-01-28)
    Comprehensive experimental resources, such as ORFeome clone libraries and deletion mutant collections, are fundamental tools for elucidation of gene function. Data sets by omics analysis using these resources provide key ...
  • Nakahigashi, Kenji; Toya, Yoshihiro; Ishii, Nobuyoshi; Soga, Tomoyoshi; Hasegawa, Miki; Watanabe, Hisami; Takai, Yuki; Honma, Masayuki; Mori, Hirotada; Tomita, Masaru (Nature Publishing Group, 2009-09-15)
    Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic ...

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