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バイオサイエンス研究科 / Graduate School of Biological Sciences

バイオサイエンス研究科 / Graduate School of Biological Sciences

 

Recent Submissions

  • Ito, Jun; Fukaki, Hidehiro; Onoda, Makoto; Li, Lin; Li, Chuanyou; Tasaka, Masao; Furutani, Masahiko (National Academy of Sciences, 2016-05-23)
    Mediator is a multiprotein complex that integrates the signals from transcription factors binding to the promoter and transmits them to achieve gene transcription. The subunits of Mediator complex reside in four modules: ...
  • Thagun, Chonprakun; Imanishi, Shunsuke; Kudo, Toru; Nakabayashi, Ryo; Ohyama, Kiyoshi; Mori, Tetsuya; Kawamoto, Koichi; Nakamura, Yukino; Katayama, Minami; Nonaka, Satoko; Matsukura, Chiaki; Yano, Kentaro; Ezura, Hiroshi; Saito, Kazuki; Hashimoto, Takashi; Shoji, Tsubasa (Oxford University Press, 2016-04-15)
    Steroidal glycoalkaloids (SGAs) are cholesterol-derived specialized metabolites produced in species of the Solanaceae. Here, we report that a group of jasmonate-responsive transcription factors of the ETHYLENE RESPONSE ...
  • Hasegawa, Junko; Sakamoto, Yuki; Nakagami, Satoru; Aida, Mitsuhiro; Sawa, Shinichiro; Matsunaga, Sachihiro (Oxford University Press, 2016-02-29)
    Clearing techniques eliminate factors that interfere with microscopic observation, including light scattering and absorption by pigments and cytoplasmic components. The techniques allow fluorescence-based detailed analyses ...
  • Okuyama-Uchimura, Fumi; Komai, Shoji (SAGE Publications, 2015-11-02)
    In contrast to the previously held notion that mice have a weak visual system, it is now generally accepted that mice can perceive rather complicated figures in various contexts such as in cognitive experiments and in ...
  • Yamada, Kohji; Yamashita‐Yamada, Misuzu; Hirase, Taishi; Fujiwara, Tadashi; Tsuda, Kenichi; Hiruma, Kei; Saijo, Yusuke (EMBO Press, 2015-11-16)
    Pathogens infect a host by suppressing defense responses induced upon recognition of microbe‐associated molecular patterns (MAMPs). Despite this suppression, MAMP receptors mediate basal resistance to limit host susceptibility, ...
  • Tanaka, Yoshiki; Sugano, Yasunori; Takemoto, Mizuki; Mori, Takaharu; Furukawa, Arata; Kusakizako, Tsukasa; Kumazaki, Kaoru; Kashima, Ayako; Ishitani, Ryuichiro; Sugita, Yuji; Nureki, Osamu; Tsukazaki, Tomoya (Elsevier, 2015-11-12)
    The bacterial SecYEG translocon functions as a conserved protein-conducting channel. Conformational transitions of SecYEG allow protein translocation across the membrane without perturbation of membrane permeability. Here, ...
  • Iwano, Megumi; Ito, Kanae; Fujii, Sota; Kakita, Mitsuru; Asano-Shimosato, Hiroko; Igarashi, Motoko; Kaothien-Nakayama, Pulla; Entani, Tetsuyuki; Kanatani, Asaka; Takehisa, Masashi; Tanaka, Masaki; Komatsu, Kunihiko; Shiba, Hiroshi; Nagai, Takeharu; Miyawaki, Atsushi; Isogai, Akira; Takayama, Seiji (Nature Publishing Group, 2015-09-01)
    Self-incompatibility in the Brassicaceae is controlled by multiple haplotypes encoding the pollen ligand (S-locus protein 11, SP11, also known as S-locus cysteine-rich protein, SCR) and its stigmatic receptor (S-receptor ...
  • Kubo, Yusuke; Baba, Kentarou; Toriyama, Michinori; Minegishi, Takunori; Sugiura, Tadao; Kozawa, Satoshi; Ikeda, Kazushi; Inagaki, Naoyuki (The Rockefeller University Press, 2015-08-17)
    Motile cells transduce environmental chemical signals into mechanical forces to achieve properly controlled migration. This signal-force transduction is thought to require regulated mechanical coupling between actin filaments ...
  • Katsuno, Hiroko; Toriyama, Michinori; Hosokawa, Yoichiroh; Mizuno, Kensaku; Ikeda, Kazushi; Sakumura, Yuichi; Inagaki, Naoyuki (Elsevier, 2015-07-16)
    Actin and actin-associated proteins migrate within various cell types. To uncover the mechanism of their migration, we analyzed actin waves, which translocate actin and actin-associated proteins along neuronal axons toward ...
  • Tanaka, Yoshiki; Hipolito, Christopher J.; Maturana, Andres D.; Ito, Koichi; Kuroda, Teruo; Higuchi, Takashi; Katoh, Takayuki; Kato, Hideaki E.; Hattori, Motoyuki; Kumazaki, Kaoru; Tsukazaki, Tomoya; Ishitani, Ryuichiro; Suga, Hiroaki; Nureki, Osamu (Nature Publishing Group, a division of Macmillan Publishers, 2013-03-27)
    Multidrug and toxic compound extrusion (MATE) family transporters are conserved in the three primary domains of life (Archaea, Bacteria and Eukarya), and export xenobiotics using an electrochemical gradient of H+ or Na+ ...
  • Doki, Shintaro; Kato, Hideaki E.; Solcan, Nicolae; Iwaki, Masayo; Koyama, Michio; Hattori, Motoyuki; Iwase, Norihiko; Tsukazaki, Tomoya; Sugita, Yuji; Kandori, Hideki; Newstead, Simon; Ishitani, yuichiro; Nureki, Osamu (National Academy of Sciences, 2013-07-09)
    Proton-dependent oligopeptide transporters (POTs) are major facilitator superfamily (MFS) proteins that mediate the uptake of peptides and peptide-like molecules, using the inwardly directed H+ gradient across the membrane. ...
  • Kumazaki, Kaoru; Tsukazaki, Tomoya; Nishizawa, Tomohiro; Tanaka, Yoshiki; Kato, Hideaki E; Nakada-Nakura, Yoshiko; Hirata, Kunio; Mori, Yoshihiro; Suga, Hiroaki; Dohmae, Naoshi; Ishitani, Ryuichiro; Nureki, Osamu (International Union of Crystallography, 2014-07-23)
    YidC, a member of the YidC/Oxa1/Alb3 family, inserts proteins into the membrane and facilitates membrane-protein folding in bacteria. YidC plays key roles in both Sec-mediated integration and Sec-independent insertion of ...
  • Mio, Kazuhiro; Tsukazaki, Tomoya; Mori, Hiroyuki; Kawata, Masaaki; Moriya, Toshio; Sasaki, Yoshikazu; Ishitani, Ryuichiro; Ito, Koreaki; Nureki, Osamu; Sato, Chikara (Springer Netherlands, 2014-09-01)
    The Sec translocon facilitates transportation of newly synthesized polypeptides from the cytoplasm to the lumen/periplasm across the phospholipid membrane. Although the polypeptide-conducting machinery is formed by the ...
  • Kumazaki, Kaoru; Kishimoto, Toshiki; Furukawa, Arata; Mori, Hiroyuki; Tanaka, Yoshiki; Dohmae, Naoshi; Ishitani, Ryuichiro; Tsukazaki, Tomoya; Nureki, Osamu (Macmillan Publishers, 2014-12-03)
    Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, ...
  • Shimokawa-Chiba, Naomi; Kumazaki, Kaoru; Tsukazaki, Tomoya; Nureki, Osamu; Ito, Koreaki; Chiba, Shinobu (National Academiy of Science, 2015-04-08)
    The recently solved crystal structure of YidC protein suggests that it mediates membrane protein insertion by means of an intramembrane cavity rather than a transmembrane (TM) pore. This concept of protein translocation ...
  • Kubo, Ken-ichi; Paape, Timothy; Hatakeyama, Masaomi; Entani, Tetsuyuki; Takara, Akie; Kajihara, Kie; Tsukahara, Mai; Shimizu-Inatsugi, Rie; Shimizu, Kentaro K.; Takayama, Seiji (Nature Publishing Group, 2015-01-08)
    Self-incompatibility (SI) systems in flowering plants distinguish self- and non-self pollen to prevent inbreeding. While other SI systems rely on the self-recognition between specific male- and female-determinants, the ...
  • Nobuaki Takahashi; Sayaka Hamada-Nakahara; Yuzuru Itoh; Kazuhiro Takemura; Atsushi Shimada; Yoshifumi Ueda; Manabu Kitamata; Rei Matsuoka; Kyoko Hanawa-Suetsugu; Yosuke Senju; Masayuki X. Mori; Shigeki Kiyonaka; Daisuke Kohda; Akio Kitao; Yasuo Mori; Shiro Suetsugu (Nature Publishing Group, 2014-09-26)
    Mutations in the ankyrin repeat domain (ARD) of ​TRPV4 are responsible for several channelopathies, including Charcot–Marie–Tooth disease type 2C and congenital distal and scapuloperoneal spinal muscular atrophy. However, ...
  • Kumazaki, Kaoru; Chiba, Shinobu; Takemoto, Mizuki; Furukawa, Arata; Nishiyama, Ken-ichi; Sugano, Yasunori; Mori, Takaharu; Dohmae, Naoshi; Hirata, Kunio; Nakada-Nakura, Yoshiko; Maturana, Andrés D.; Tanaka, Yoshiki; Mori, Hiroyuki; Sugita, Yuji; Arisaka, Fumio; Ito, Koreaki; Ishitani, Ryuichiro; Tsukazaki, Tomoya; Nureki, Osamu (Nature Publishing Group, 2014-05-22)
    Newly synthesized membrane proteins must be accurately inserted into the membrane, folded and assembled for proper functioning. The protein YidC inserts its substrates into the membrane, thereby facilitating membrane protein ...
  • Furutani, Masahiko; Nakano, Yasukazu; Tasaka, Masao (National Academiy of Science, 2014-01-21)
    In Arabidopsis, leaves and flowers form cyclically in the shoot meristem periphery and are triggered by local accumulations of the plant hormone auxin. Auxin maxima are established by the auxin efflux carrier PIN-FORMED1 ...
  • Takahashi, Naoki; Kajihara, Takehiro; Okamura, Chieko; Kim, Yoonhee; Katagiri, Youhei; Okushima, Yoko; Matsunaga, Sachihiro; Hwang, Ildoo; Umeda, Masaaki (Elsevier, 2013-09-12)
    Plant roots respond to various internal and external signals and adjust themselves to changes of environmental conditions. In the root meristem, stem cells produce daughter cells that continue to divide several times. When ...

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