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バイオサイエンス研究科 / Graduate School of Biological Sciences

バイオサイエンス研究科 / Graduate School of Biological Sciences

 

Recent Submissions

  • Kanda, Satoshi; Yanagitani, Kota; Yokota, Yukiko; Esaki, Yuta; Kohno, Kenji (National Academy of Sciences of the United States of America, 2016-09-20)
    Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress ...
  • Kitano, Ken (Frontiers Media, 2014-10-29)
    The RecQ family DNA helicases WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) play a key role in protecting the genome against deleterious changes. In humans, mutations in these proteins lead to rare genetic ...
  • 北野, 健 (日本結晶学会, 2015-05-01)
    The RecQ family of DNA helicases play a key role in protecting the genome against deleterious changes. In humans, mutations in the members WRN (Werner syndrome protein) and BLM (Bloom syndrome protein) respectively lead ...
  • 北野, 健 (日本生物物理学会, 2014-09-30)
  • Kim, Sun-Yong; Hakoshima, Toshio; Kitano, Ken (Nature Publishing Group, 2013-11-21)
    Bloom syndrome is a rare genetic disorder characterized by genomic instability and cancer predisposition. The disease is caused by mutations of the Bloom syndrome protein (BLM). Here we report the crystal structure of a ...
  • Kim, Sun-Yong; Tachioka, Yuka; Mori, Tomoyuki; Hakoshima, Toshio (Nature Publishing Group, 2016-06-23)
    MOB1 protein is a key regulator of large tumor suppressor 1/2 (LATS1/2) kinases in the Hippo pathway. MOB1 is present in an autoinhibited form and is activated by MST1/2-mediated phosphorylation, although the precise ...
  • Montero, Manuel; Rahimpour, Mehdi; Viale, Alejandro M.; Almagro, Goizeder; Eydallin, Gustavo; Sevilla, Angel; Canovas, Manuel; Bernal, Cristina; Lozano, Ana Belen; Munoz, Francisco Jose; Baroja-Fernandez, Edurne; Bahaji, Abdellatif; Mori, Hirotada; Codoner, Francisco M.; Pozueta-Romero, Javier (Public Library of Science, 2014-09-04)
    In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function ...
  • Yamamoto, Tatsuo; Takano, Tomomi; Higuchi, Wataru; Iwao, Yasuhisa; Singur, Olga; Reva, Ivan; Otsuka, Yuta; Nakayashiki, Toru; Mori, Hirotada; Reva, Galina; Kuznetsov, Vladimir; Potapov, Vladimir (Public Library of Science, 2012-01-19)
    Two distinct classes of methicillin-resistant Staphylococcus aureus (MRSA) are spreading in hospitals (as hospital-acquired MRSA, HA-MRSA) and in the community (as community-acquired MRSA, CA-MRSA). Multilocus sequence ...
  • Aoki, Wataru; Saito, Masato; Manabe, Ri-ichiroh; Mori, Hirotada; Yamaguchi, Yoshinori; Tamiya, Eiichi (Nature Publishing Group, 2014-04-17)
    We propose ‘integrated synthetic genetics’ as a novel methodology that integrates reductive and synthetic approaches used in life science research. Integrated synthetic genetics enables determinations of sets of genes ...
  • Rajagopala, Seesandra V; Titz, Bjorn; Goll, Johannes; Parrish, Jodi R; Wohlbold, Katrin; McKevitt, Matthew T; Palzkill, Timothy; Mori, Hirotada; Finley, Russell L; Uetz, Peter (Nature Publishing Group, 2007-07-31)
    Motility is achieved in most bacterial species by the flagellar apparatus. It consists of dozens of different proteins with thousands of individual subunits. The published literature about bacterial chemotaxis and flagella ...
  • Usui, Yuki; Hirasawa, Takashi; Furusawa, Chikara; Shirai, Tomokazu; Yamamoto, Natsuko; Mori, Hirotada; Shimizu, Hiroshi (BioMed Central Ltd, 2012-06-21)
    It has long been recognized that analyzing the behaviour of the complex intracellular biological networks is important for breeding industrially useful microorganisms. However, because of the complexity of these biological ...
  • Tian, Zhongyuan; Faure, Adrien; Mori, Hirotada; Matsuno, Hiroshi (BioMed Central Ltd, 2013-12-13)
    Glycogen and glucose are two sugar sources available during the lag phase of E. coli, but the mechanism that regulates their utilization is still unclear.
  • Otsuka, Yuta; Muto, Ai; Takeuchi, Rikiya; Okada, Chihiro; Ishikawa, Motokazu; Nakamura, Koichiro; Yamamoto, Natsuko; Dose, Hitomi; Nakahigashi, Kenji; Tanishima, Shigeki; Suharnan, Sivasundaram; Nomura, Wataru; Nakayashiki, Toru; Aref, Walid G.; Bochner, Barry R.; Conway, Tyrrell; Gribskov, Michael; Kihara, Daisuke; Rudd, Kenneth E.; Tohsato, Yukako; Wanner, Barry L.; Mori, Hirotada (Oxford University Press, 2015-01-28)
    Comprehensive experimental resources, such as ORFeome clone libraries and deletion mutant collections, are fundamental tools for elucidation of gene function. Data sets by omics analysis using these resources provide key ...
  • Nakahigashi, Kenji; Toya, Yoshihiro; Ishii, Nobuyoshi; Soga, Tomoyoshi; Hasegawa, Miki; Watanabe, Hisami; Takai, Yuki; Honma, Masayuki; Mori, Hirotada; Tomita, Masaru (Nature Publishing Group, 2009-09-15)
    Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic ...
  • Yamamoto, Natsuko; Nakahigashi, Kenji; Nakamichi, Tomoko; Yoshino, Mihoko; Takai, Yuki; Touda, Yae; Furubayashi, Akemi; Kinjyo, Satoko; Dose, Hitomi; Hasegawa, Miki; Datsenko, Kirill A; Nakayashiki, Toru; Tomita, Masaru; Wanner, Barry L; Mori, Hirotada (Nature Publishing Group, 2009-12-22)
    The Keio collection (Baba et al, 2006) has been established as a set of single‐gene deletion mutants of Escherichia coli K‐12. These mutants have a precisely designed deletion from the second codon from the seventh to the ...
  • Takeuchi, Rikiya; Tamura, Takeyuki; Nakayashiki, Toru; Tanaka, Yuichirou; Muto, Ai; Wanner, Barry L.; Mori, Hirotada (BioMed Central Ltd, 2014-06-26)
    Precise quantitative growth measurements and detection of small growth changes in high-throughput manner is essential for fundamental studies of bacterial cell. However, an inherent tradeoff for measurement quality in ...
  • Nakahigashi, Kenji; Takai, Yuki; Shiwa, Yuh; Wada, Mei; Honma, Masayuki; Yoshikawa, Hirofumi; Tomita, Masaru; Kanai, Akio; Mori, Hirotada (BioMed Central Ltd, 2014-12-16)
    There is a significant difference between synonymous codon usage in many organisms, and it is known that codons used more frequently generally showed efficient decoding rate. At the gene level, however, there are conflicting ...
  • Shinhara, Atsuko; Matsui, Motomu; Hiraoka, Kiriko; Nomura, Wataru; Hirano, Reiko; Nakahigashi, Kenji; Tomita, Masaru; Mori, Hirotada; Kanai, Akio (BioMed Central Ltd, 2011-08-24)
    In Escherichia coli, approximately 100 regulatory small RNAs (sRNAs) have been identified experimentally and many more have been predicted by various methods. To provide a comprehensive overview of sRNAs, we analysed the ...
  • Khan, Ishita; Chen, Yuqian; Dong, Tiange; Hong, Xioawei; Takeuchi, Rikiya; Mori, Hirotada; Kihara, Daisuke (BioMed Central Ltd, 2014-12-11)
    Moonlighting proteins perform two or more cellular functions, which are selected based on various contexts including the cell type they are expressed, their oligomerization status, and the binding of different ligands at ...
  • CRMP 
    久保, 祐亮; 稲垣, 直之 (理化学研究所 脳科学総合研究センター, 2012-10-26)
    コラプシン反応媒介タンパク質(collapsin response mediator proteins, CRMPs)は、軸索の反発性因子であるセマフォリン3A(Sema3A)の細胞内シグナルを伝達する分子として最初に同定された。CRMPsは、細胞質タンパク質であり、これまでに5つのサブタイプ(CRMP1~5)が同定されている。これらの発現は主に発生時期の神経系に認められ、それぞれ特異的な発現分布と発現時期を示す。CRMPsは線虫Unc ...

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