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Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase.

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dc.contributor.author Laurence, Cromer
dc.contributor.author Sylvie, Jolivet
dc.contributor.author Dipesh Kumar, Singh
dc.contributor.author Floriane, Berthier
dc.contributor.author Nancy De, Winne
dc.contributor.author Geert De, Jaeger
dc.contributor.author Komaki, Shinichiro
dc.contributor.author Maria Ada, Prusicki
dc.contributor.author Arp, Schnittger
dc.contributor.author Raphael, Guérois
dc.contributor.author Raphael, Mercier
dc.date.accessioned 2019-12-11T08:28:31Z
dc.date.available 2019-12-11T08:28:31Z
dc.date.issued 2019-07-19
dc.identifier.issn 1091-6490
dc.identifier.uri http://hdl.handle.net/10061/13951
dc.description PNAS August 6, 2019 116 (32) 16018-16027; first published July 19, 2019 ja_JP
dc.description.abstract Accurate chromosome segregation at mitosis and meiosis is crucial to prevent genome instability, birth defect, and cancer. Accordingly, separase, the protease that triggers chromosome distribution, is tightly regulated by a direct inhibitor, the securin. However, securin has not been identified, neither functionnally nor by sequence similarity, in other clades that fungi and animals. This raised doubts about the conservation of this mechanism in other branches of eukaryotes. Here, we identify and characterize the securin in plants. Despite extreme sequence divergence, the securin kept the same core function and is likely a universal regulator of cell division in eukaryotes. ja_JP
dc.language.iso en ja_JP
dc.publisher National Academy of Sciences ja_JP
dc.rights Copyright © 2019 the Author(s). Published by PNAS. ja_JP
dc.title Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase. ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription コマキ, シンイチロウ
dc.contributor.alternative 小牧, 伸一郎
dc.textversion publisher ja_JP
dc.identifier.jtitle PNAS ja_JP
dc.identifier.volume 116 ja_JP
dc.identifier.spage 16018 ja_JP
dc.identifier.epage 16027 ja_JP
dc.relation.doi info:doi/10.1073/pnas.1906237116 ja_JP
dc.identifier.artnum 32 ja_JP
dc.identifier.NAIST-ID 74654146 ja_JP


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