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Stress-sensing and regulatory mechanism of the endoplasmic-stress sensors Ire1 and PERK

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dc.contributor.author Ishiwata-Kimata, Yuki
dc.contributor.author Giang, Quynh Le
dc.contributor.author Kimata, Yukio
dc.date.accessioned 2019-10-31T08:59:12Z
dc.date.available 2019-10-31T08:59:12Z
dc.date.issued 2018-10-26
dc.identifier.issn 2300-4266
dc.identifier.uri http://hdl.handle.net/10061/13405
dc.description.abstract Ire1 and its family protein PERK are endoplasmic reticulum (ER)-stress sensors that initiate cellular responses against ER accumulation of unfolded proteins. As reviewed in this article, many publications describe molecular mechanisms by which yeast Ire1 senses ER conditions and gets regulated. We also cover recent studies which reveal that mammalian Ire1 (IRE1α) and PERK are controlled in a similar but not exactly the same manner. ER-located molecular chaperone BiP captures these ER-stress sensors and suppresses their activity. Intriguingly, Ire1 is associated with BiP not as a chaperone substrate, but as a unique ligand. Unfolded proteins accumulated in the ER promote dissociation of the Ire1-BiP complex. Moreover, Ire1 is directly bound with unfolded proteins, leading to its cluster formation and potent activation. PERK also captures unfolded proteins and then forms self-oligomers. Meanwhile, membrane-lipid aberrancy is likely to activate these ER-stress sensors independently of ER accumulation of unfolded proteins. In addition, there exist a number of reports that touch on other factors that control activity of these ER-stress sensors. Such a multiplicity of regulatory mechanisms for these ER-stress sensors is likely to contribute to fine tuning of their activity. ja_JP
dc.language.iso en ja_JP
dc.publisher De Gruyter ja_JP
dc.subject endoplasmic reticulum stress ja_JP
dc.subject sensor ja_JP
dc.subject unfolded protein ja_JP
dc.title Stress-sensing and regulatory mechanism of the endoplasmic-stress sensors Ire1 and PERK ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription キマタ, ユキオ
dc.contributor.alternative 木俣, 行雄
dc.textversion publisher ja_JP
dc.identifier.jtitle Endoplasmic Reticulum Stress in Diseases ja_JP
dc.identifier.volume 5 ja_JP
dc.identifier.issue 1 ja_JP
dc.identifier.spage 1 ja_JP
dc.identifier.epage 10 ja_JP
dc.relation.doi doi.org/10.1515/ersc-2018-0001 ja_JP
dc.identifier.NAIST-ID 84365071 ja_JP
dc.identifier.NAIST-ID 73290140 ja_JP


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