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A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

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dc.contributor.author Takahashi, Naoki
dc.contributor.author Ogita, Nobuo
dc.contributor.author Takahashi, Tomonobu
dc.contributor.author Taniguchi, Shoji
dc.contributor.author Tanaka, Maho
dc.contributor.author Seki, Motoaki
dc.contributor.author Umeda, Masaaki
dc.date.accessioned 2019-04-11T02:05:52Z
dc.date.available 2019-04-11T02:05:52Z
dc.date.issued 2019-04-04
dc.identifier.other 2050-084X
dc.identifier.uri http://hdl.handle.net/10061/13132
dc.description.abstract Cell cycle arrest is an active response to stresses that enables organisms to survive under fluctuating environmental conditions. While signalling pathways that inhibit cell cycle progression have been elucidated, the putative core module orchestrating cell cycle arrest in response to various stresses is still elusive. Here we report that in Arabidopsis, the NAC-type transcription factors ANAC044 and ANAC085 are required for DNA damage-induced G2 arrest. Under genotoxic stress conditions, ANAC044 and ANAC085 enhance protein accumulation of the R1R2R3-type Myb transcription factor (Rep-MYB), which represses G2/M-specific genes. ANAC044/ANAC085-dependent accumulation of Rep-MYB and cell cycle arrest are also observed in the response to heat stress that causes G2 arrest, but not to osmotic stress that retards G1 progression. These results suggest that plants deploy the ANAC044/ANAC085-mediated signalling module as a hub which perceives distinct stress signals and leads to G2 arrest. ja_JP
dc.language.iso en ja_JP
dc.publisher eLife Sciences Publications, Ltd ja_JP
dc.rights © 2019, Takahashi et al. ja_JP
dc.rights This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. ja_JP
dc.subject cell cycle arrest ja_JP
dc.subject DNA damage ja_JP
dc.subject heat stress ja_JP
dc.subject transcription factors ja_JP
dc.subject protein stability ja_JP
dc.subject gene expression ja_JP
dc.title A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription タカハシ, ナオキ
dc.contributor.transcription オギタ, ノブオ
dc.contributor.transcription タカハシ, トモノブ
dc.contributor.transcription タニグチ, ショウジ
dc.contributor.transcription タナカ, マホ
dc.contributor.transcription セキ, モトアキ
dc.contributor.transcription ウメダ, マサアキ
dc.contributor.alternative 高橋, 直紀
dc.contributor.alternative 荻田, 伸夫
dc.contributor.alternative 高橋, 知伸
dc.contributor.alternative 谷口, 昌司
dc.contributor.alternative 田中, 真帆
dc.contributor.alternative 関, 原明
dc.contributor.alternative 梅田, 正明
dc.identifier.fulltexturl https://elifesciences.org/articles/43944 ja_JP
dc.textversion publisher ja_JP
dc.identifier.jtitle eLife ja_JP
dc.identifier.volume 8 ja_JP
dc.relation.doi info:doi/doi: 10.7554/eLife.43944 ja_JP
dc.identifier.artnum e43944 ja_JP
dc.identifier.NAIST-ID 73294654 ja_JP
dc.identifier.NAIST-ID 83515221 ja_JP
dc.identifier.NAIST-ID 85628030 ja_JP
dc.identifier.NAIST-ID 85628089 ja_JP
dc.identifier.NAIST-ID 73290587 ja_JP
dc.relation.pmid 30944065 ja_JP


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