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Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons

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dc.contributor.author Huang, Liguo
dc.contributor.author Urasak, Akihiro
dc.contributor.author Inagaki, Naoyuki
dc.date.accessioned 2019-04-08T01:33:33Z
dc.date.available 2019-04-08T01:33:33Z
dc.date.issued 2019-02-12
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10061/13130
dc.description.abstract Rab small GTPases play key roles in intracellular membrane trafficking. Rab33a promotes axon outgrowth of cultured rat hippocampal neurons by mediating the anterograde axonal transport of Golgi-derived vesicles and the concomitant exocytosis of these vesicles at the growth cone. However, the functions of Rab33 in vivo are unclear. Here, we show that zebrafish rab33a and rab33ba are orthologs of mammalian Rab33a and Rab33b, respectively. They are expressed in the developing brain, including in neurons of the telencephalic dorsorostral cluster and the diencephalic ventrorostral cluster, which project axons to form the anterior and postoptic commissures, respectively. Although rab33a single mutant and rab33ba single mutant fish did not show remarkable defects, fish carrying the rab33a;rab33ba double mutations displayed dysgenesis of the anterior and postoptic commissures. Single-cell labeling in the telencephalic dorsorostral cluster demonstrated that the rab33a;rab33ba double mutation inhibits axonal extension in the anterior commissure. These results suggest that Rab33a and Rab33ba mediate axon outgrowth and the formation of the forebrain commissures in the zebrafish brain in a cooperative manner. ja_JP
dc.language.iso en ja_JP
dc.publisher Springer Nature ja_JP
dc.rights © The Author(s) 2019 ja_JP
dc.title Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons ja_JP
dc.type.nii Journal Article ja_JP
dc.contributor.transcription ウラサキ, アキヒロ
dc.contributor.transcription イナガキ, ナオユキ
dc.contributor.alternative 浦崎, 明宏
dc.contributor.alternative 稲垣, 直之
dc.identifier.fulltexturl https://doi.org/10.1038/s41598-018-38468-5 ja_JP
dc.textversion publisher ja_JP
dc.identifier.jtitle Scientific Reports ja_JP
dc.identifier.volume 9 ja_JP
dc.identifier.issue 1 ja_JP
dc.identifier.spage 1799 ja_JP
dc.relation.doi info:doi/10.1038/s41598-018-38468-5 ja_JP
dc.identifier.NAIST-ID 03252227 ja_JP
dc.identifier.NAIST-ID 62177903 ja_JP
dc.relation.pmid 30755680 ja_JP

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