• ABA inhibits root cell elongation through repressing the cytokinin signaling 

  Takatsuka, Hirotomo; Umeda, Masaaki (Taylor & Francis, 2019-02-09)

  Cell elongation, which plays an important role in root penetration into the soil, responds to a variety of environmental factors. A previous study demonstrated that abscisic acid, a phytohormone involved in stress responses, ...
• Cytokinin signaling coordinates development of diverse organs in Marchantia polymorpha 

  Aki, Shoiri S.; Nishihama, Ryuichi; Kohchi, Takayuki; Umeda, Ｍａｓａａｋｉ (Taylor & Francis, 2019-09-18)

  Cytokinins play an essential role in plant growth and development. A recent study showed that the cytokinin signaling pathway was conserved in the liverwort Marchantia polymorpha, and that it controlled gemma cup and rhizoid ...
• Gap 2 phase: making the fundamental decision to divide or not 

  Umeda, Masaak; Shiori S, Aki; Naoki, Takahashi (Elsevier, 2019-04-05)

  The Gap phases of the cell cycle are essential to perceive internal and external signals and control cell division and differentiation. However, our knowledge of molecular mechanisms underlying G2 progression in plants ...
• Integration of transcriptional repression and Polycomb-mediated silencing of WUSCHEL in floral meristems 

  Bo, Sun; Zhou, Yingying; Cai, Jie; Shang, Erlei; Yamaguchi, Nobutoshi; Xiao, Jun; Looi, Liang-Sheng; Wee, Wan-Yi; Gao, Xiuying; Wagner, Doris; Ito, Toshiro (AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, 2019-07-01)

  Arabidopsis (Arabidopsis thaliana) floral meristems terminate after the carpel primordia arise. This is achieved through the temporal repression of WUSCHEL (WUS), which is essential for stem cell maintenance. At floral ...
• Tubulin lattice in cilia is in a stressed form regulated by microtubule inner proteins 

  Ichikawa, Muneyoshi; Khalifa, Ahmad Abdelzaher Zaki; Kubo, Shintaroh; Dai, Daniel; Basu, Kaustuv; Maghrebi, Mohammad Amin Faghfor; Vargas, Javier; Bui, Khanh Huy (National Academy of Sciences, 2019-09-16)

  Cilia, the hair-like protrusions that beat at high frequencies to propel a cell or move fluid around are composed of radially bundled doublet microtubules. In this study, we present a near-atomic resolution map of the ...
• Membrane-deformation ability of ANKHD1 is involved in the early endosome enlargement 

  Kitamata, Manabu; Hanawa-Suetsugu, Kyoko; Maruyama, Kohei; Suetsugu, Shiro (Elsevier (Cell Press), 2019-07-26)

  Ankyrin-repeat domains (ARDs) are conserved in large numbers of proteins. ARDs are composed of various numbers of ankyrin repeats (ANKs). ARDs often adopt curved structures reminiscent of the Bin-Amphiphysin-Rvs (BAR) ...
• Structural Basis of the Sec Translocon and YidC Revealed Through X-ray Crystallography 

  Tsukazaki, Tomoya (Springer US, 2019-04)
• RNF152 Negatively Regulates mTOR Signalling and Blocks Cell Proliferation in the Floor Plate 

  Kadoya, Minori; Sasai, Noriaki (Cold Spring Harbor Laboratory, 2019-05-23)

  The neural tube is composed of a number of neural progenitors and postmitotic neurons distributed in a quantitatively and spatially precise manner. The floor plate, located in the ventral-most region of the neural tube, ...
• GPR17 is an essential regulator for the temporal adaptation of Sonic hedgehog signalling in neural tube development 

  Yatsuzuka, Atsuki; Hori, Akiko; Kadoya, Minori; Matsuo-Takasaki, Mami; Kondo, Toru; Sasai, Noriaki (Company of Biologists: Development, 2019-08-23)

  Dorsal-ventral pattern formation of the neural tube is regulated by temporal and spatial activities of extracellular signalling molecules. Sonic hedgehog (Shh) assigns ventral neural subtypes via activation of the Gli ...
• Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system 

  Urasaki, Akihiro; Morishita, Seiya; Naka, Kosuke; Uozumi, Minato; Abe, Kouki; Huang, Liguo; Watase, Emiko; Nakagawa, Osamu; Kawakami, Koichi; Matsui, Takaaki; Bessho, Yasumasa; Inagaki, Naoyuki (Springer Nature, 2019-08-21)

  The zebrafish sensory posterior lateral line is an excellent model system to study collective cell migration and organogenesis. Shootin1 is a cytoplasmic protein involved in neuronal polarization and axon guidance. Previous ...
• Cytokinin Signaling Is Essential for Organ Formation in Marchantia polymorpha 

  Aki, Shiori; Mikami, Tatsuya; Naramoto, Satoshi; Nishihama, Ryuichi; Ishizaki, Kimitsune; Kojima, Mikiko; Takebayashi, Yumiko; Sakakibara, Hitoshi; Kyozuka, Junko; Kohchi, Takayuki; Umeda, Masaaki (Oxford University Press, 2019-05-28)

  Cytokinins are known to regulate various physiological events in plants. Cytokinin signaling is mediated by the phosphorelay system, one of the most ancient mechanisms controlling hormonal pathways in plants. The liverwort ...
• Single-Unit Imaging of Membrane Protein-Embedded Nanodiscs from Two Oriented Sides by High-Speed Atomic Force Microscopy 

  Tanaka, Yoshiki; Tsukazaki, Tomoya (Elsevier, 2019-01-02)
• Structural Basis for the Function of the β-Barrel Assembly-Enhancing Protease BepA 

  Tanaka, Yoshiki; Hayashi, Yugo; Kamikubo, Hironari; Tsukazaki, Tomoya (Elsevier, 2019-02-01)

  The β-barrel assembly machinery (BAM) complex mediates the assembly of β-barrel membrane proteins in the outer membrane. BepA, formerly known as YfgC, interacts with the BAM complex and functions as a protease/chaperone ...
• 2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop 

  Tanaka, Yoshiki; Tsukazaki, Tomoya (Elsevier, 2018-10-20)

  YidC/Alb3/Oxa1 family proteins are involved in the insertion and assembly of membrane proteins. The core five transmembrane regions of YidC, which are conserved in the protein family, form a positively charged cavity open ...
• Shootin1による細胞-基質間の力の発生を介した神経細胞の細胞移動，極性形成，軸索ガイダンスおよびアクチン波 

  稲垣, 直之 (公益社団法人日本生化学会, 2019-04-25)

  Shootin1はクラッチ分子として重合・脱重合を繰り返すアクチン線維と細胞接着分子を連結することで細胞と細胞外基質の間に牽引力を生み出す．さらに，この力の発生はシグナル伝達によって調節を受ける．本稿では，最近のShootin1の解析を通じて明らかとなりつつある神経細胞の極性形成，軸索ガイダンス，細胞移動そして新たな細胞内分子輸送機構アクチン波の分子メカニクスを解説する．
• Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay 

  塚崎, 智也; 田中, 良樹 (Elsevier Inc., 2019-04-23)

  Sarco/endoplasmic reticulum (ER) Ca2+-ATPase 2b (SERCA2b) is a ubiquitously expressed membrane protein that facilitates Ca2+ uptake from the cytosol to the ER. SERCA2b includes a characteristic 11th transmembrane helix ...
• Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons 

  Huang, Liguo; Urasak, Akihiro; Inagaki, Naoyuki (Springer Nature, 2019-02-12)

  Rab small GTPases play key roles in intracellular membrane trafficking. Rab33a promotes axon outgrowth of cultured rat hippocampal neurons by mediating the anterograde axonal transport of Golgi-derived vesicles and the ...
• ERK Activity Dynamics during Zebrafish Embryonic Development 

  Wong, Kah-Loon; Akiyama, Ryutaro; Bessho, Yasumasa; Matsui, Takaaki (MDPI, 2018-12-28)

  During vertebrate development, extracellular signal-regulated kinase (ERK) is activated by growth factors such as fibroblast growth factor (FGF), and it regulates the formation of tissues/organs including eyes, brains, ...
• Editorial: Cell Adhesion and Migration in the Development of Multicellular Organisms 

  Takaaki, Matsui (Frontiers, 2018-10-22)
• Noise-resistant developmental reproducibility in vertebrate somite formation 

  Honda, Naoki; Akiyama, Ryutaro; Sari, Dini Wahyu Kartika; Ishii, Shin; Bessho, Yasumasa; Matsui, Takaaki (Public Library of Science, 2019-02-04)

  The reproducibility of embryonic development is remarkable, although molecular processes are intrinsically stochastic at the single-cell level. How the multicellular system resists the inevitable noise to acquire developmental ...

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